Generation of an integration-free induced pluripotent stem cell line (CSC-43J) from a patient with sporadic Parkinson's disease

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Generation of an integration-free induced pluripotent stem cell line (CSC-43J) from a patient with sporadic Parkinson's disease. / Marote, Ana; Pomeshchik, Yuriy; Goldwurm, Stefano; Collin, Anna; Lamas, Nuno J.; Pinto, Luísa; Salgado, António J.; Roybon, Laurent.

In: Stem Cell Research, Vol. 27, 01.03.2018, p. 82-85.

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Marote, Ana ; Pomeshchik, Yuriy ; Goldwurm, Stefano ; Collin, Anna ; Lamas, Nuno J. ; Pinto, Luísa ; Salgado, António J. ; Roybon, Laurent. / Generation of an integration-free induced pluripotent stem cell line (CSC-43J) from a patient with sporadic Parkinson's disease. In: Stem Cell Research. 2018 ; Vol. 27. pp. 82-85.

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TY - JOUR

T1 - Generation of an integration-free induced pluripotent stem cell line (CSC-43J) from a patient with sporadic Parkinson's disease

AU - Marote, Ana

AU - Pomeshchik, Yuriy

AU - Goldwurm, Stefano

AU - Collin, Anna

AU - Lamas, Nuno J.

AU - Pinto, Luísa

AU - Salgado, António J.

AU - Roybon, Laurent

PY - 2018/3/1

Y1 - 2018/3/1

N2 - An induced pluripotent stem cell (iPSC) line was generated from a 36-year-old patient with sporadic Parkinson's disease (PD). Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated cell line (CSC-43) exhibits expression of common pluripotency markers, in vitro differentiation into three germ layers and normal karyotype. This iPSC line can be used to study the mechanisms underlying the development of PD.

AB - An induced pluripotent stem cell (iPSC) line was generated from a 36-year-old patient with sporadic Parkinson's disease (PD). Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated cell line (CSC-43) exhibits expression of common pluripotency markers, in vitro differentiation into three germ layers and normal karyotype. This iPSC line can be used to study the mechanisms underlying the development of PD.

U2 - 10.1016/j.scr.2018.01.007

DO - 10.1016/j.scr.2018.01.007

M3 - Article

VL - 27

SP - 82

EP - 85

JO - Stem Cell Research

T2 - Stem Cell Research

JF - Stem Cell Research

SN - 1876-7753

ER -