Generation of Transplantable Striatal Projection Neurons from Human ESCs.

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Abstract

In this issue of Cell Stem Cell, Ma et al. (2012) report a differentiation protocol for generating striatal projection neurons from human embryonic stem cells with high efficiency. The cells survive transplantation, reconnect striatal circuitry, and restore motor function in a mouse model of striatal neurodegeneration that mimics the central pathohology of Huntington's disease.

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  • Cell Biology
Original languageEnglish
Pages (from-to)349-350
JournalCell Stem Cell
Volume10
Issue number4
Publication statusPublished - 2012
Publication categoryResearch
Peer-reviewedYes