Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies

Research output: Contribution to journalReview article

Abstract

There are data to support a role for genetic and immune-related factors in the pathogenesis of lymphomas and plasma cell diseases. In this paper, we review our published large population-based studies and other relevant studies in Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma, and the precursor condition monoclonal gammopathy of undetermined significance. We discuss the overlap in risk factors between related malignancies and explore the underlying mechanisms. Based on these studies, we provide clinical implications and discuss the relevance of these data for patient counseling and clinical follow-up. Finally, we suggest future directions for new studies designed to increase our current knowledge and to define underlying biological mechanisms of our findings.

Details

Authors
  • Sigurdur Y. Kristinsson
  • Lynn R. Goldin
  • Magnus Bjorkholm
  • Jill Koshiol
  • Ingemar Turesson
  • Ola Landgren
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology

Keywords

  • susceptibility, familial aggregation, multiple myeloma, MGUS, lymphoma, Waldenstrom's macroglobulinemia, lymphoplasmacytic lymphoma, leukemia, chronic lymphocytic, Hodgkin's lymphoma, non-Hodgkin's lymphoma, immune-related, autoimmune disease, rheumatoid arthritis, monoclonal, B-cell lymphocytosis
Original languageEnglish
Pages (from-to)1581-1589
JournalHaematologica
Volume94
Issue number11
Publication statusPublished - 2009
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)