Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies

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Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies. / Kristinsson, Sigurdur Y.; Goldin, Lynn R.; Bjorkholm, Magnus; Koshiol, Jill; Turesson, Ingemar; Landgren, Ola.

In: Haematologica, Vol. 94, No. 11, 2009, p. 1581-1589.

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Kristinsson, Sigurdur Y. ; Goldin, Lynn R. ; Bjorkholm, Magnus ; Koshiol, Jill ; Turesson, Ingemar ; Landgren, Ola. / Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies. In: Haematologica. 2009 ; Vol. 94, No. 11. pp. 1581-1589.

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TY - JOUR

T1 - Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies

AU - Kristinsson, Sigurdur Y.

AU - Goldin, Lynn R.

AU - Bjorkholm, Magnus

AU - Koshiol, Jill

AU - Turesson, Ingemar

AU - Landgren, Ola

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)

PY - 2009

Y1 - 2009

N2 - There are data to support a role for genetic and immune-related factors in the pathogenesis of lymphomas and plasma cell diseases. In this paper, we review our published large population-based studies and other relevant studies in Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma, and the precursor condition monoclonal gammopathy of undetermined significance. We discuss the overlap in risk factors between related malignancies and explore the underlying mechanisms. Based on these studies, we provide clinical implications and discuss the relevance of these data for patient counseling and clinical follow-up. Finally, we suggest future directions for new studies designed to increase our current knowledge and to define underlying biological mechanisms of our findings.

AB - There are data to support a role for genetic and immune-related factors in the pathogenesis of lymphomas and plasma cell diseases. In this paper, we review our published large population-based studies and other relevant studies in Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma, and the precursor condition monoclonal gammopathy of undetermined significance. We discuss the overlap in risk factors between related malignancies and explore the underlying mechanisms. Based on these studies, we provide clinical implications and discuss the relevance of these data for patient counseling and clinical follow-up. Finally, we suggest future directions for new studies designed to increase our current knowledge and to define underlying biological mechanisms of our findings.

KW - susceptibility

KW - familial aggregation

KW - multiple myeloma

KW - MGUS

KW - lymphoma

KW - Waldenstrom's macroglobulinemia

KW - lymphoplasmacytic lymphoma

KW - leukemia

KW - chronic lymphocytic

KW - Hodgkin's lymphoma

KW - non-Hodgkin's lymphoma

KW - immune-related

KW - autoimmune disease

KW - rheumatoid arthritis

KW - monoclonal

KW - B-cell lymphocytosis

U2 - 10.3324/haematol.2009.008979

DO - 10.3324/haematol.2009.008979

M3 - Review article

VL - 94

SP - 1581

EP - 1589

JO - Haematologica-The Hematology Journal

T2 - Haematologica-The Hematology Journal

JF - Haematologica-The Hematology Journal

SN - 1592-8721

IS - 11

ER -