Genetic dissection of autoimmune type I diabetes in the BB rat

Research output: Contribution to journalArticle


The BB rat is among the best models of insulin−dependent diabetes mellitus — with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T−cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.


  • Howard J. Jacob
  • Anna Pettersson
  • Deborah Wilson
  • Yipei Mao
  • Åke Lernmark
  • Eric S. Lander
External organisations
  • Whitehead Institute for Biomedical Research
  • Massachusetts Institute of Technology
  • University of Washington
Original languageEnglish
Pages (from-to)56-60
JournalNature Genetics
Issue number1
Publication statusPublished - 1992 Jan 1
Publication categoryResearch
Externally publishedYes