Genetic dissection of autoimmune type I diabetes in the BB rat

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Bibtex

@article{9461819125f6433893381f18050fa9e7,
title = "Genetic dissection of autoimmune type I diabetes in the BB rat",
abstract = "The BB rat is among the best models of insulin−dependent diabetes mellitus — with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T−cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.",
author = "Jacob, {Howard J.} and Anna Pettersson and Deborah Wilson and Yipei Mao and {\AA}ke Lernmark and Lander, {Eric S.}",
year = "1992",
month = "1",
day = "1",
doi = "10.1038/ng0992-56",
language = "English",
volume = "2",
pages = "56--60",
journal = "Nature Genetics",
issn = "1546-1718",
publisher = "Nature Publishing Group",
number = "1",

}