Genetic dissection of autoimmune type I diabetes in the BB rat

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Genetic dissection of autoimmune type I diabetes in the BB rat. / Jacob, Howard J.; Pettersson, Anna; Wilson, Deborah; Mao, Yipei; Lernmark, Åke; Lander, Eric S.

In: Nature Genetics, Vol. 2, No. 1, 01.01.1992, p. 56-60.

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Harvard

Jacob, HJ, Pettersson, A, Wilson, D, Mao, Y, Lernmark, Å & Lander, ES 1992, 'Genetic dissection of autoimmune type I diabetes in the BB rat', Nature Genetics, vol. 2, no. 1, pp. 56-60. https://doi.org/10.1038/ng0992-56

APA

Jacob, H. J., Pettersson, A., Wilson, D., Mao, Y., Lernmark, Å., & Lander, E. S. (1992). Genetic dissection of autoimmune type I diabetes in the BB rat. Nature Genetics, 2(1), 56-60. https://doi.org/10.1038/ng0992-56

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Jacob, Howard J. ; Pettersson, Anna ; Wilson, Deborah ; Mao, Yipei ; Lernmark, Åke ; Lander, Eric S. / Genetic dissection of autoimmune type I diabetes in the BB rat. In: Nature Genetics. 1992 ; Vol. 2, No. 1. pp. 56-60.

RIS

TY - JOUR

T1 - Genetic dissection of autoimmune type I diabetes in the BB rat

AU - Jacob, Howard J.

AU - Pettersson, Anna

AU - Wilson, Deborah

AU - Mao, Yipei

AU - Lernmark, Åke

AU - Lander, Eric S.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - The BB rat is among the best models of insulin−dependent diabetes mellitus — with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T−cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.

AB - The BB rat is among the best models of insulin−dependent diabetes mellitus — with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T−cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.

UR - http://www.scopus.com/inward/record.url?scp=0026922594&partnerID=8YFLogxK

U2 - 10.1038/ng0992-56

DO - 10.1038/ng0992-56

M3 - Article

VL - 2

SP - 56

EP - 60

JO - Nature Genetics

JF - Nature Genetics

SN - 1546-1718

IS - 1

ER -