Genetic diversity in hepatitis C virus in Egypt and possible association with hepatocellular carcinoma

Research output: Contribution to journalArticle

Abstract

Egypt has one of the world's highest prevalences of hepatitis C virus (HCV) infection, with a majority of genotype 4 infections. To explore the genetic diversity of HCV in Egypt, sera from 131 Egyptians [56 from community studies, 37 chronic hepatitis patients, 28 hepatocellular carcinoma (HCC) patients and 10 patients with non-Hodgkin's lymphoma] were genotyped by restriction fragment-length polymorphism and phylogenetic analyses of sequences from the mid-core and non-structural 5B regions. The different genotyping methods showed good agreement. The majority of the viruses (83 of 131; 63 %) were of subtype 4a, but five other subtypes within genotype 4 were also observed, as well as three genotype 1b, five genotype 1g and one genotype 3a samples. Interestingly, subtype 4o, which was easily identifiable in all three genomic regions, 3 showed an association with HCC (P=0.017), which merits further investigation.

Details

Authors
  • Mohamed Abdel-Hamid
  • Mai El-Daly
  • Vilma Molnegren
  • Sherif El-Kafrawy
  • Sohair Abdel-Latif
  • Gamal Esmat
  • G. Thomas Strickland
  • Christopher Loffredo
  • Jan Albert
  • Anders Widell
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology in the medical area
Original languageEnglish
Pages (from-to)1526-1531
JournalJournal of General Virology
Volume88
Issue number5
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes