Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts

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Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. / Kotronen, Anna; Yki-Jarvinen, Hannele; Aminoff, Anna; Bergholm, Robert; Pietilainen, Kirsi H.; Westerbacka, Jukka; Talmud, Philippa J.; Humphries, Steve E.; Hamsten, Anders; Isomaa, Bo; Groop, Leif; Orho-Melander, Marju; Ehrenborg, Ewa; Fisher, Rachel M.

In: European Journal of Endocrinology, Vol. 160, No. 4, 2009, p. 593-602.

Research output: Contribution to journalArticle

Harvard

Kotronen, A, Yki-Jarvinen, H, Aminoff, A, Bergholm, R, Pietilainen, KH, Westerbacka, J, Talmud, PJ, Humphries, SE, Hamsten, A, Isomaa, B, Groop, L, Orho-Melander, M, Ehrenborg, E & Fisher, RM 2009, 'Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts', European Journal of Endocrinology, vol. 160, no. 4, pp. 593-602. https://doi.org/10.1530/EJE-08-0900

APA

Kotronen, A., Yki-Jarvinen, H., Aminoff, A., Bergholm, R., Pietilainen, K. H., Westerbacka, J., ... Fisher, R. M. (2009). Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. European Journal of Endocrinology, 160(4), 593-602. https://doi.org/10.1530/EJE-08-0900

CBE

Kotronen A, Yki-Jarvinen H, Aminoff A, Bergholm R, Pietilainen KH, Westerbacka J, Talmud PJ, Humphries SE, Hamsten A, Isomaa B, Groop L, Orho-Melander M, Ehrenborg E, Fisher RM. 2009. Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. European Journal of Endocrinology. 160(4):593-602. https://doi.org/10.1530/EJE-08-0900

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Kotronen, Anna ; Yki-Jarvinen, Hannele ; Aminoff, Anna ; Bergholm, Robert ; Pietilainen, Kirsi H. ; Westerbacka, Jukka ; Talmud, Philippa J. ; Humphries, Steve E. ; Hamsten, Anders ; Isomaa, Bo ; Groop, Leif ; Orho-Melander, Marju ; Ehrenborg, Ewa ; Fisher, Rachel M. / Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. In: European Journal of Endocrinology. 2009 ; Vol. 160, No. 4. pp. 593-602.

RIS

TY - JOUR

T1 - Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts

AU - Kotronen, Anna

AU - Yki-Jarvinen, Hannele

AU - Aminoff, Anna

AU - Bergholm, Robert

AU - Pietilainen, Kirsi H.

AU - Westerbacka, Jukka

AU - Talmud, Philippa J.

AU - Humphries, Steve E.

AU - Hamsten, Anders

AU - Isomaa, Bo

AU - Groop, Leif

AU - Orho-Melander, Marju

AU - Ehrenborg, Ewa

AU - Fisher, Rachel M.

PY - 2009

Y1 - 2009

N2 - Aims: We investigated whether polymorph isms in candidate genes involved in lipid metabolism and type 2 diabetes are related to liver I, at content. Methods: Liver fat content was measured using proton magnetic resonance spectroscopy (H-1-MRS) in 302 Finns, in whom single nucleotide polymorphisms (SNPs) in acyl-CoA synthetase long-chain family member 4 (ACSL4). acliponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2), and the three peroxisome proliferator-activated receptors (PPARA, PPARD, and PPARG) were analyzed. To validate our findings, SNPs significantly associated with liver fat content were Studied in two independent cohorts and related to surrogate markers of liver fat content. Results: In the Finnish subjects, polymorphisms in ACSL4 (rs7887981), ADIPOR2 (rs767870), and PPARG (rs3856806) were significantly associated with liver fat content measured with H-1-MRS after adjusting for age, gender, and BMI, Anthropometric and circulating parameters were comparable between genotypes. In the first validation cohort of similar to 600 Swedish men, ACSL4 rs7887981 was related to fasting insulin and triglyceride concentrations, and ADIPOR2 rs767870 to serum gamma glutamyltransfer concentrations after adjusting for BMI. The SNP in PPARG (rs3856806) was not significantly associated with any relevant metabolic parameter in this cohort. In the second validation cohort of similar to 3000 subjects from Western Finland, ADIPOR2 rs767870, but not ACSL4 rs7887981 was related to fasting triglyceride concentrations. Conclusions: Genetic variation, particularly in the ADIPOR2 gene, contributes to variation in hepatic fat accumulation in humans.

AB - Aims: We investigated whether polymorph isms in candidate genes involved in lipid metabolism and type 2 diabetes are related to liver I, at content. Methods: Liver fat content was measured using proton magnetic resonance spectroscopy (H-1-MRS) in 302 Finns, in whom single nucleotide polymorphisms (SNPs) in acyl-CoA synthetase long-chain family member 4 (ACSL4). acliponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2), and the three peroxisome proliferator-activated receptors (PPARA, PPARD, and PPARG) were analyzed. To validate our findings, SNPs significantly associated with liver fat content were Studied in two independent cohorts and related to surrogate markers of liver fat content. Results: In the Finnish subjects, polymorphisms in ACSL4 (rs7887981), ADIPOR2 (rs767870), and PPARG (rs3856806) were significantly associated with liver fat content measured with H-1-MRS after adjusting for age, gender, and BMI, Anthropometric and circulating parameters were comparable between genotypes. In the first validation cohort of similar to 600 Swedish men, ACSL4 rs7887981 was related to fasting insulin and triglyceride concentrations, and ADIPOR2 rs767870 to serum gamma glutamyltransfer concentrations after adjusting for BMI. The SNP in PPARG (rs3856806) was not significantly associated with any relevant metabolic parameter in this cohort. In the second validation cohort of similar to 3000 subjects from Western Finland, ADIPOR2 rs767870, but not ACSL4 rs7887981 was related to fasting triglyceride concentrations. Conclusions: Genetic variation, particularly in the ADIPOR2 gene, contributes to variation in hepatic fat accumulation in humans.

U2 - 10.1530/EJE-08-0900

DO - 10.1530/EJE-08-0900

M3 - Article

VL - 160

SP - 593

EP - 602

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 1479-683X

IS - 4

ER -