Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.

Research output: Contribution to journalArticle

Abstract

Although a genetic contribution to ischemic stroke is well recognized, only a handful of stroke loci have been identified by large-scale genetic association studies to date. Hypothesizing that genetic effects might be stronger for early- versus late-onset stroke, we conducted a 2-stage meta-analysis of genome-wide association studies, focusing on stroke cases with an age of onset <60 years.

Details

Authors
  • Yu-Ching Cheng
  • Tara M Stanne
  • Anne-Katrin Giese
  • Weang Kee Ho
  • Matthew Traylor
  • Philippe Amouyel
  • Elizabeth G Holliday
  • Rainer Malik
  • Huichun Xu
  • Steven J Kittner
  • John W Cole
  • Jeffrey R O'Connell
  • John Danesh
  • Asif Rasheed
  • Wei Zhao
  • Stefan Engelter
  • Caspar Grond-Ginsbach
  • Yoichiro Kamatani
  • Mark Lathrop
  • Didier Leys
  • Vincent Thijs
  • Tiina M Metso
  • Turgut Tatlisumak
  • Alessandro Pezzini
  • Eugenio A Parati
  • Steve Bevan
  • Peter M Rothwell
  • Cathie Sudlow
  • Agnieszka Slowik
  • Matthew R Walters
  • Jim Jannes
  • Jess Shen
  • David Crosslin
  • Kimberly Doheny
  • Cathy C Laurie
  • Sandip M Kanse
  • Joshua C Bis
  • Myriam Fornage
  • Thomas H Mosley
  • Jemma C Hopewell
  • Konstantin Strauch
  • Martina Müller-Nurasyid
  • Christian Gieger
  • Melanie Waldenberger
  • Annette Peters
  • Christine Meisinger
  • M Arfan Ikram
  • W T Longstreth
  • James F Meschia
  • Sudha Seshadri
  • Pankaj Sharma
  • Bradford Worrall
  • Christina Jern
  • Christopher Levi
  • Martin Dichgans
  • Giorgio B Boncoraglio
  • Hugh S Markus
  • Stephanie Debette
  • Arndt Rolfs
  • Danish Saleheen
  • Braxton D Mitchell
Organisations
External organisations
  • University of Maryland
  • University of Gothenburg
  • University of Rostock
  • University of Nottingham
  • University of Cambridge
  • Pasteur Institute of Lille
  • University of Newcastle
  • Ludwig-Maximilian University of Munich
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
Original languageEnglish
Pages (from-to)307-316
JournalStroke; a journal of cerebral circulation
Volume47
Issue number2
Publication statusPublished - 2016
Publication categoryResearch
Peer-reviewedYes