Genome-wide linkage analysis in families with infantile hypertrophic pyloric stenosis indicates novel susceptibility loci

Research output: Contribution to journalArticle

Abstract

Infantile hypertrophic pyloric stenosis (IHPS) is a common cause of upper gastrointestinal obstruction during infancy. A multifactorial background of the disease is well established. Multiple susceptibility loci including the neuronal nitric oxide synthase (NOS1) gene have previously been linked to IHPS, but contradictory results of linkage studies in different materials indicate genetic heterogeneity. To identify IHPS susceptibility loci, we conducted a genome-wide linkage analysis in 37 Swedish families. In regions where the Swedish material showed most evidence in favor of linkage, 31 additional British IHPS families were analyzed. Evidence in favor of significant linkage was observed in the Swedish material to two loci on chromosome 2q24 (non-parametric linkage (NPL)=3.77) and 7p21 (NPL=4.55). In addition, evidence of suggestive linkage was found to two loci on chromosome 6p21 (NPL=2.97) and 12q24 (NPL=2.63). Extending the material with British samples did not enhance the level of significance. Regions with linkage harbor interesting candidate genes, such as glucagon-like peptide-2 (GLP-2 encoded by the glucagon gene GCG), NOS1, motilin (MLN) and neuropeptide Y (NPY). The coding exons for GLP-2, and NPY were screened for mutations with negative results. In conclusion, we could confirm suggestive linkage to the region harboring the NOS1 gene and detected additional novel susceptibility loci for IHPS. Journal of Human Genetics (2012) 57, 115-121; doi:10.1038/jhg.2011.137; published online 8 December 2011

Details

Authors
  • Anna Svenningsson
  • Cilla Soderhall
  • Sofia Persson
  • Fredrik Lundberg
  • Holger Luthman
  • Eddie Chung
  • Mark Gardiner
  • Ingrid Kockum
  • Agneta Nordenskjold
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Genetics

Keywords

  • families, infantile hypertrophic pyloric stenosis, linkage
Original languageEnglish
Pages (from-to)115-121
JournalJournal of Human Genetics
Volume57
Issue number2
Publication statusPublished - 2012
Publication categoryResearch
Peer-reviewedYes