Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

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title = "Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults",
abstract = "Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23{\%} of participants were categorized as inactive and 77{\%} as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30{\%} in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.",
author = "Mariaelisa Graff and Scott, {Robert A.} and Justice, {Anne E} and Young, {Kristin L.} and Feitosa, {Mary F.} and Llilda Barata and Winkler, {Thomas W} and Chu, {Audrey Y.} and Anubha Mahajan and David Hadley and Luting Xue and Tsegaselassie Workalemahu and Heard-Costa, {Nancy L.} and {den Hoed}, Marcel and Ahluwalia, {Tarunveer S} and Qibin Qi and Ngwa, {Julius S} and Frida Renstr{\"o}m and Lydia Quaye and Eicher, {John D.} and Hayes, {James E} and Marilyn Cornelis and Zoltan Kutalik and Elise Lim and Jian’an Luan and Huffman, {Jennifer E} and Weihua Zhang and Wei Zhao and Griffin, {Paula J.} and Toomas Haller and Shafqat Ahmad and Pedro Marques-Vidal and Stephanie Bien and Loic Yengo and Alexander Teumer and Smith, {Albert Vernon} and Meena Kumari and Harder, {Marie Neergaard} and Justesen, {Johanne Marie} and Kleber, {Marcus E} and Mette Hollensted and Kurt Lohman and Rivera, {Natalia V.} and Whitfield, {John B} and Zhao, {Jing Hua} and Stringham, {Heather M.} and Leo-Pekka Lyytik{\"a}inen and Charlotte Huppertz and Gonneke Willemsen and Franks, {Paul W.} and {CHARGE Consortium} and {EPIC-InterAct Consortium} and {PAGE Consortium}",
year = "2017",
month = "4",
day = "1",
doi = "10.1371/journal.pgen.1006528",
language = "English",
volume = "13",
journal = "PLoS Genetics",
issn = "1553-7404",
publisher = "Public Library of Science",
number = "4",