Genomic Profiles of Neuroblastoma Associated With Opsoclonus Myoclonus Syndrome

Research output: Contribution to journalArticle

Abstract

Opsoclonus myoclonus syndrome (OMS), often called "dancing eyed syndrome," is a rare neurological condition associated with neuroblastoma in the majority of all childhood cases. Genomic copy number profiles have shown to be of prognostic significance for neuroblastoma patients. The aim of this retrospective multicenter study was to analyze the genomic copy number profiles of tumors from children with neuroblastoma presenting with OMS at diagnosis. In 44 cases of neuroblastoma associated with OMS, overall genomic profiling by either array-comparative genomic hybridization or single nucleotide polymorphism array proved successful in 91% of the cases, distinguishing tumors harboring segmental chromosome alterations from those with numerical chromosome alterations only. A total of 23/44 (52%) tumors showed an segmental chromosome alterations genomic profile, 16/44 (36%) an numerical chromosome alterations genomic profile, and 1 case displayed an atypical profile (12q amplicon). No recurrently small interstitial copy number alterations were identified. With no tumor relapse nor disease-related deaths, the overall genomic profile was not of prognostic impact with regard to the oncological outcome in this series of patients. Thus, the observation of an excellent oncological outcome, even for those with an unfavorable genomic profile of neuroblastoma, supports the hypothesis that an immune response might be involved in tumor control in these patients with OMS.

Details

Authors
  • Barbara Hero
  • Nathalie Clement
  • Ingrid Øra
  • Gaelle Pierron
  • Eve Lapouble
  • Jessica Theissen
  • Claudia Pasqualini
  • Dominique Valteau-Couanet
  • Dominique Plantaz
  • Jean Michon
  • Olivier Delattre
  • Marc Tardieu
  • Gudrun Schleiermacher
Organisations
External organisations
  • University of Cologne
  • Curie Institute, Paris
  • Skåne University Hospital
  • Institut Gustave Roussy
  • Grenoble University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
Pages (from-to)93-98
JournalJournal of Pediatric Hematology/Oncology
Volume40
Issue number2
Early online date2017 Nov 13
Publication statusPublished - 2018
Publication categoryResearch
Peer-reviewedYes