Gerronemins A-F, cytotoxic biscatechols from a Gerronema species

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Abstract

The gerronemins A-F (1-6) were isolated as the cytotoxic components of an extract of a Gerronema species detected in a screening for new cytotoxic metabolites from basidiomycetes. Their structures were elucidated by spectroscopic techniques, and they are composed of a C-12-C-16 alkane or alkene substituted at both ends by 2,3-dihydroxyphenyl groups. The gerronemins blocked the inducible expression of a hCOX-2 and iNOS promoter driven reporter gene with IC50-values of 1-5 mug/ml. In addition, cytotoxic activities were observed which were due the inhibition of cellular macromolecular syntheses.

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Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry

Keywords

  • cytotoxic activity, biscatechols, Gerronema, gerronemins A-F
Original languageEnglish
Pages (from-to)643-648
JournalPhytochemistry
Volume59
Issue number6
Publication statusPublished - 2002
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)