Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation.

Research output: Contribution to journalArticle


Psychiatric, physical and biological aspects of posttraumatic stress disorder (PTSD) may be associated with dysfunctions in several cellular processes including nitric oxide (NO) production. NO is synthesized from arginine in a reaction carried out by NO synthase (NOS) enzymes. The recently introduced "global arginine bioavailability ratio" (GABR; ratio of arginine to [ornithine+ citrulline]) has been proposed as a reliable approximation of NO synthetic capacity in vivo. The objectives of the present study were to test the hypotheses that (i) subjects with combat-related PTSD have lower GABR scores than combat controls, (ii) GABR score is inversely associated with the severity of psychopathological measures, (iii) GABR score is inversely associated with markers of inflammation.


  • Francesco Saverio Bersani
  • Owen M Wolkowitz
  • Daniel Lindqvist
  • Rachel Yehuda
  • Janine Flory
  • Linda M Bierer
  • Iouri Makotine
  • Duna Abu-Amara
  • Michelle Coy
  • Victor I Reus
  • Elissa S Epel
  • Charles Marmar
  • Synthia H Mellon
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Psychiatry
Original languageEnglish
Pages (from-to)153-160
JournalBrain Behavior and Immunity
Issue numberoct 26
Publication statusPublished - 2016
Publication categoryResearch