Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.

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Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB. / Berglund, Lisa; Lyssenko, Valeriya; Ladenvall, Claes; Kotova, Olga; Edsfeldt, Andreas; Pilgaard, Kasper; Alkayyali, Sami; Brøns, Charlotte; Forsblom, Carol; Jonsson, Anna; Zetterqvist, Anna; Nitulescu, Mihaela; Ruiz McDavitt, Christian; Dunér, Pontus; Stancáková, Alena; Kuusisto, Johanna; Ahlqvist, Emma; Lajer, Maria; Tarnow, Lise; Madsbad, Sten; Rossing, Peter; Kieffer, Timothy J; Melander, Olle; Orho-Melander, Marju; Nilsson, Peter; Groop, Per-Henrik; Vaag, Allan; Lindblad, Bengt; Gottsäter, Anders; Laakso, Markku; Goncalves, Isabel; Groop, Leif; Gomez, Maria.

In: Diabetes, Vol. 65, No. 1, 2016, p. 239-254.

Research output: Contribution to journalArticle

Harvard

Berglund, L, Lyssenko, V, Ladenvall, C, Kotova, O, Edsfeldt, A, Pilgaard, K, Alkayyali, S, Brøns, C, Forsblom, C, Jonsson, A, Zetterqvist, A, Nitulescu, M, Ruiz McDavitt, C, Dunér, P, Stancáková, A, Kuusisto, J, Ahlqvist, E, Lajer, M, Tarnow, L, Madsbad, S, Rossing, P, Kieffer, TJ, Melander, O, Orho-Melander, M, Nilsson, P, Groop, P-H, Vaag, A, Lindblad, B, Gottsäter, A, Laakso, M, Goncalves, I, Groop, L & Gomez, M 2016, 'Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.', Diabetes, vol. 65, no. 1, pp. 239-254. https://doi.org/10.2337/db15-0122

APA

Berglund, L., Lyssenko, V., Ladenvall, C., Kotova, O., Edsfeldt, A., Pilgaard, K., Alkayyali, S., Brøns, C., Forsblom, C., Jonsson, A., Zetterqvist, A., Nitulescu, M., Ruiz McDavitt, C., Dunér, P., Stancáková, A., Kuusisto, J., Ahlqvist, E., Lajer, M., Tarnow, L., ... Gomez, M. (2016). Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB. Diabetes, 65(1), 239-254. https://doi.org/10.2337/db15-0122

CBE

Berglund L, Lyssenko V, Ladenvall C, Kotova O, Edsfeldt A, Pilgaard K, Alkayyali S, Brøns C, Forsblom C, Jonsson A, Zetterqvist A, Nitulescu M, Ruiz McDavitt C, Dunér P, Stancáková A, Kuusisto J, Ahlqvist E, Lajer M, Tarnow L, Madsbad S, Rossing P, Kieffer TJ, Melander O, Orho-Melander M, Nilsson P, Groop P-H, Vaag A, Lindblad B, Gottsäter A, Laakso M, Goncalves I, Groop L, Gomez M. 2016. Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB. Diabetes. 65(1):239-254. https://doi.org/10.2337/db15-0122

MLA

Vancouver

Author

Berglund, Lisa ; Lyssenko, Valeriya ; Ladenvall, Claes ; Kotova, Olga ; Edsfeldt, Andreas ; Pilgaard, Kasper ; Alkayyali, Sami ; Brøns, Charlotte ; Forsblom, Carol ; Jonsson, Anna ; Zetterqvist, Anna ; Nitulescu, Mihaela ; Ruiz McDavitt, Christian ; Dunér, Pontus ; Stancáková, Alena ; Kuusisto, Johanna ; Ahlqvist, Emma ; Lajer, Maria ; Tarnow, Lise ; Madsbad, Sten ; Rossing, Peter ; Kieffer, Timothy J ; Melander, Olle ; Orho-Melander, Marju ; Nilsson, Peter ; Groop, Per-Henrik ; Vaag, Allan ; Lindblad, Bengt ; Gottsäter, Anders ; Laakso, Markku ; Goncalves, Isabel ; Groop, Leif ; Gomez, Maria. / Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB. In: Diabetes. 2016 ; Vol. 65, No. 1. pp. 239-254.

RIS

TY - JOUR

T1 - Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.

AU - Berglund, Lisa

AU - Lyssenko, Valeriya

AU - Ladenvall, Claes

AU - Kotova, Olga

AU - Edsfeldt, Andreas

AU - Pilgaard, Kasper

AU - Alkayyali, Sami

AU - Brøns, Charlotte

AU - Forsblom, Carol

AU - Jonsson, Anna

AU - Zetterqvist, Anna

AU - Nitulescu, Mihaela

AU - Ruiz McDavitt, Christian

AU - Dunér, Pontus

AU - Stancáková, Alena

AU - Kuusisto, Johanna

AU - Ahlqvist, Emma

AU - Lajer, Maria

AU - Tarnow, Lise

AU - Madsbad, Sten

AU - Rossing, Peter

AU - Kieffer, Timothy J

AU - Melander, Olle

AU - Orho-Melander, Marju

AU - Nilsson, Peter

AU - Groop, Per-Henrik

AU - Vaag, Allan

AU - Lindblad, Bengt

AU - Gottsäter, Anders

AU - Laakso, Markku

AU - Goncalves, Isabel

AU - Groop, Leif

AU - Gomez, Maria

PY - 2016

Y1 - 2016

N2 - Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with extrapancreatic effects beyond glycemic control. Here we demonstrate unexpected effects of GIP signaling in the vasculature. GIP induces the expression of the pro-atherogenic cytokine osteopontin (OPN) in mouse arteries, via local release of endothelin-1 (ET-1) and activation of cAMP response element binding protein (CREB). Infusion of GIP increases plasma OPN levels in healthy individuals. Plasma ET-1 and OPN levels are positively correlated in patients with critical limb ischemia. Fasting GIP levels are higher in individuals with a history of cardiovascular disease (myocardial infarction, stroke) when compared to controls. GIP receptor (GIPR) and OPN mRNA levels are higher in carotid endarterectomies from patients with symptoms (stroke, transient ischemic attacks, amaurosis fugax) than in asymptomatic patients; and expression associates to parameters characteristic of unstable and inflammatory plaques (increased lipid accumulation, macrophage infiltration and reduced smooth muscle cell content). While GIPR expression is predominantly endothelial in healthy arteries from human, mouse, rat and pig; remarkable up-regulation is observed in endothelial and smooth muscle cells upon culture conditions yielding a "vascular disease-like" phenotype. Moreover, a common variant rs10423928 in the GIPR gene associated with increased risk of stroke in type 2 diabetes patients.

AB - Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with extrapancreatic effects beyond glycemic control. Here we demonstrate unexpected effects of GIP signaling in the vasculature. GIP induces the expression of the pro-atherogenic cytokine osteopontin (OPN) in mouse arteries, via local release of endothelin-1 (ET-1) and activation of cAMP response element binding protein (CREB). Infusion of GIP increases plasma OPN levels in healthy individuals. Plasma ET-1 and OPN levels are positively correlated in patients with critical limb ischemia. Fasting GIP levels are higher in individuals with a history of cardiovascular disease (myocardial infarction, stroke) when compared to controls. GIP receptor (GIPR) and OPN mRNA levels are higher in carotid endarterectomies from patients with symptoms (stroke, transient ischemic attacks, amaurosis fugax) than in asymptomatic patients; and expression associates to parameters characteristic of unstable and inflammatory plaques (increased lipid accumulation, macrophage infiltration and reduced smooth muscle cell content). While GIPR expression is predominantly endothelial in healthy arteries from human, mouse, rat and pig; remarkable up-regulation is observed in endothelial and smooth muscle cells upon culture conditions yielding a "vascular disease-like" phenotype. Moreover, a common variant rs10423928 in the GIPR gene associated with increased risk of stroke in type 2 diabetes patients.

U2 - 10.2337/db15-0122

DO - 10.2337/db15-0122

M3 - Article

C2 - 26395740

VL - 65

SP - 239

EP - 254

JO - Diabetes

JF - Diabetes

SN - 1939-327X

IS - 1

ER -