Glucose-sensing mechanisms in pancreatic beta-cells

Research output: Contribution to journalArticle

Abstract

The appropriate secretion of insulin from pancreatic beta-cells is critically important to the maintenance of energy homeostasis. The beta-cells must sense and respond suitably to postprandial increases of blood glucose, and perturbation of glucose-sensing in these cells can lead to hypoglycaemia or hyperglycaemias and ultimately diabetes. Here, we review beta-cell glucose-sensing with a particular focus on the regulation of cellular excitability and exocytosis. We examine in turn: (i) the generation of metabolic signalling molecules; (ii) the regulation of beta-cell membrane potential; and (iii) insulin granule dynamics and exocytosis. We further discuss the role of well known and putative candidate metabolic signals as regulators of insulin secretion.

Details

Authors
  • Patrick MacDonald
  • JW Joseph
  • Patrik Rorsman
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes

Keywords

  • potential, membrane, ion channels, metabolism, glucose, insulin secretion, exocytosis
Original languageEnglish
Pages (from-to)2211-2225
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume360
Issue number1464
Publication statusPublished - 2005
Publication categoryResearch
Peer-reviewedYes