Glucose-sensing mechanisms in pancreatic beta-cells

Research output: Contribution to journalArticle


title = "Glucose-sensing mechanisms in pancreatic beta-cells",
abstract = "The appropriate secretion of insulin from pancreatic beta-cells is critically important to the maintenance of energy homeostasis. The beta-cells must sense and respond suitably to postprandial increases of blood glucose, and perturbation of glucose-sensing in these cells can lead to hypoglycaemia or hyperglycaemias and ultimately diabetes. Here, we review beta-cell glucose-sensing with a particular focus on the regulation of cellular excitability and exocytosis. We examine in turn: (i) the generation of metabolic signalling molecules; (ii) the regulation of beta-cell membrane potential; and (iii) insulin granule dynamics and exocytosis. We further discuss the role of well known and putative candidate metabolic signals as regulators of insulin secretion.",
keywords = "potential, membrane, ion channels, metabolism, glucose, insulin secretion, exocytosis",
author = "Patrick MacDonald and JW Joseph and Patrik Rorsman",
year = "2005",
doi = "10.1098/rstb.2005.1762",
language = "English",
volume = "360",
pages = "2211--2225",
journal = "Philosophical Transactions of the Royal Society B: Biological Sciences",
issn = "1471-2970",
publisher = "Royal Society",
number = "1464",