Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring

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Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring. / Ivarsson, Sten-A.; Ackefors, Malin; Ekberg, Göran; Falorni, Alberto; Kockum, Ingrid; Landin-Olsson, Mona; Lernmark, Åke; Lindberg, Bengt; Sundkvist, Göran; Svanberg, Lars; Carlsson, Annelie.

In: Autoimmunity, Vol. 26, No. 4, 08.11.1997, p. 261-269.

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T1 - Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring

AU - Ivarsson, Sten-A.

AU - Ackefors, Malin

AU - Ekberg, Göran

AU - Falorni, Alberto

AU - Kockum, Ingrid

AU - Landin-Olsson, Mona

AU - Lernmark, Åke

AU - Lindberg, Bengt

AU - Sundkvist, Göran

AU - Svanberg, Lars

AU - Carlsson, Annelie

PY - 1997/11/8

Y1 - 1997/11/8

N2 - We studied the risk for diabetes of glutamate decarboxylase (GAD65Ab) and islet cell (ICA) autoantibodies in non-diabetic pregnant mothers and their children. Pregnancy and cord blood sera were collected in 1970-87 from about 35,000 mothers who delivered a child in the city of Malmo, Sweden. A total of 42 mothers were identified in 1988 who, 1-18 years after their pregnancies, had developed either insulin-dependent (n = 22) or non-insulin dependent (n = 20) diabetes mellitus. First, in 123 pregnant mothers selected as controls, 0.8% had GAD65Ab and 0.8% ICA. Second, among the mothers with non-insulin dependent diabetes, 7/20 (35%) had GAD65Ab eight months to 13 years, 10 months before clinical diagnosis. Third, in mothers who later developed insulin-dependent diabetes, 12/22 (55%) had GAD65Ab and 10/22 (45%) had ICA in pregnancies preceding the clinical diagnosis by 13 months to 9 years, 4 months. In 1996, none of the children born to the 42 mothers have developed diabetes. GAD65Ab and ICA in non-diabetic pregnancies may predict insulin-dependent diabetes in the mother but not necessarily in the offspring.

AB - We studied the risk for diabetes of glutamate decarboxylase (GAD65Ab) and islet cell (ICA) autoantibodies in non-diabetic pregnant mothers and their children. Pregnancy and cord blood sera were collected in 1970-87 from about 35,000 mothers who delivered a child in the city of Malmo, Sweden. A total of 42 mothers were identified in 1988 who, 1-18 years after their pregnancies, had developed either insulin-dependent (n = 22) or non-insulin dependent (n = 20) diabetes mellitus. First, in 123 pregnant mothers selected as controls, 0.8% had GAD65Ab and 0.8% ICA. Second, among the mothers with non-insulin dependent diabetes, 7/20 (35%) had GAD65Ab eight months to 13 years, 10 months before clinical diagnosis. Third, in mothers who later developed insulin-dependent diabetes, 12/22 (55%) had GAD65Ab and 10/22 (45%) had ICA in pregnancies preceding the clinical diagnosis by 13 months to 9 years, 4 months. In 1996, none of the children born to the 42 mothers have developed diabetes. GAD65Ab and ICA in non-diabetic pregnancies may predict insulin-dependent diabetes in the mother but not necessarily in the offspring.

KW - Autoimmunity

KW - Glutamic acid decarboxylase

KW - HLA

KW - Islet cell autoantibodies

KW - Placental transfer

KW - Pregnancy

KW - autoantibody

KW - enzyme antibody

KW - glutamate decarboxylase

KW - pancreas islet cell antibody

KW - adult

KW - article

KW - clinical article

KW - controlled study

KW - female

KW - human

KW - insulin dependent diabetes mellitus

KW - non insulin dependent diabetes mellitus

KW - risk

KW - Sweden

M3 - Article

VL - 26

SP - 261

EP - 269

JO - Autoimmunity

JF - Autoimmunity

SN - 0891-6934

IS - 4

ER -