Glycogen metabolism in the glucose-sensing and supply-driven β-cell

Research output: Contribution to journalLetter

Abstract

Glycogen metabolism in β-cells may affect downstream metabolic pathways controlling insulin release. We examined glycogen metabolism in human islets and in the rodent-derived INS-1 832/13 β-cells and found them to express the same isoforms of key enzymes required for glycogen metabolism. Our findings indicate that glycogenesis is insulin-independent but influenced by extracellular glucose concentrations. Levels of glycogen synthase decrease with increasing glucose concentrations, paralleling accumulation of glycogen. We did not find cAMP-elicited glycogenolysis and insulin secretion to be causally related. In conclusion, our results reveal regulated glycogen metabolism in human islets and insulin-secreting cells. Whether glycogen metabolism affects insulin secretion under physiological conditions remains to be determined.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology

Keywords

  • human islets, INS-1 832/13, insulin secretion
Original languageEnglish
Pages (from-to)4242-4251
Number of pages10
JournalFEBS Letters
Volume590
Issue number23
Publication statusPublished - 2016 Dec 1
Publication categoryResearch
Peer-reviewedYes