Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus

Research output: Contribution to journalReview article


Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus (iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles. iNPH and Alzheimer's disease (AD) both exhibit sleep disturbances, build-up of brain metabolic wastes and amyloid-β (Aβ) plaques, perivascular reactive astrogliosis, and mislocalization of astrocyte aquaporin-4 (AQP4). The glia–lymphatic (glymphatic) system facilitates brain fluid clearance and waste removal during sleep via glia-supported perivascular channels. Human studies have implicated impaired glymphatic function in both AD and iNPH. Continued investigation into the role of glymphatic system biology in AD and iNPH models could lead to new strategies to improve brain health by restoring homeostatic brain metabolism and CSF dynamics.


  • Benjamin C. Reeves
  • Jason K. Karimy
  • Adam J. Kundishora
  • Humberto Mestre
  • H. Mert Cerci
  • Charles Matouk
  • Seth L. Alper
  • Iben Lundgaard
  • Maiken Nedergaard
  • Kristopher T. Kahle
External organisations
  • Yale University
  • University of Rochester Medical Center
  • Harvard Medical School
  • University of Copenhagen
  • Istanbul University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
  • Neurosciences


  • aging, Alzheimer's disease, dementia, glial-lymphatic, glymphatic, hydrocephalus, idiopathic normal pressure hydrocephalus
Original languageEnglish
JournalTrends in Molecular Medicine
Publication statusE-pub ahead of print - 2020
Publication categoryResearch