GPR30/GPER1: searching for a role in estrogen physiology.

Research output: Contribution to journalArticle

Standard

GPR30/GPER1: searching for a role in estrogen physiology. / Olde, Björn; Leeb-Lundberg, Fredrik.

In: Trends in Endocrinology and Metabolism, Vol. 20, 2009, p. 409-416.

Research output: Contribution to journalArticle

Harvard

APA

CBE

MLA

Vancouver

Author

RIS

TY - JOUR

T1 - GPR30/GPER1: searching for a role in estrogen physiology.

AU - Olde, Björn

AU - Leeb-Lundberg, Fredrik

PY - 2009

Y1 - 2009

N2 - Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional membrane estrogen receptor involved in non-genomic estrogen signaling. However, this function is not universally accepted. Studies concerning the role of GPER1 in vivo are now beginning to appear but with divergent results. In this review we discuss current knowledge on the physiological role of GPER1 in the nervous system as well as in reproduction, metabolism, bone, and in the cardiovascular and immune systems.

AB - Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional membrane estrogen receptor involved in non-genomic estrogen signaling. However, this function is not universally accepted. Studies concerning the role of GPER1 in vivo are now beginning to appear but with divergent results. In this review we discuss current knowledge on the physiological role of GPER1 in the nervous system as well as in reproduction, metabolism, bone, and in the cardiovascular and immune systems.

U2 - 10.1016/j.tem.2009.04.006

DO - 10.1016/j.tem.2009.04.006

M3 - Article

VL - 20

SP - 409

EP - 416

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1879-3061

ER -