Graded error signals in eyeblink conditioning

Research output: Contribution to journalReview article

Abstract

Minimizing errors is an important aspect of learning. However, it is not enough merely to record if an error occurred. For efficient learning, information about the magnitude of errors is critical. Did my tennis swing completely miss the target or did I hit the ball, but not quite in the sweet spot? How can neurons – which have traditionally been thought of as binary units – signal the magnitude of an error? Here I review evidence that eyeblink conditioning – a basic form of motor learning – depends on graded signals from the inferior olive which guides plasticity in the cerebellum and ultimately tunes behavior. Specifically, evidence suggests that: (1)Error signals are conveyed to the cerebellum via the inferior olive; (2)Signals from the inferior olive are graded; (3)The strength of the olivary signal affects learning; (4)Cerebellar feedback influences the strength of the olivary signal. I end the review by exploring how graded error signals might explain some behavioral learning phenomena.

Details

Authors
Organisations
External organisations
  • Erasmus University Medical Center
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • Cerebellum, Climbing fibers, Error signals, Eyeblink conditioning, Inferior olive, Learning, Nucleo-Olivary pathway, Plasticity, Rescorla-Wagner
Original languageEnglish
JournalNeurobiology of Learning and Memory
Publication statusE-pub ahead of print - 2019 Apr 21
Publication categoryResearch
Peer-reviewedYes