Graded error signals in eyeblink conditioning

Research output: Contribution to journalReview article

Standard

Graded error signals in eyeblink conditioning. / Rasmussen, Anders.

In: Neurobiology of Learning and Memory, 21.04.2019.

Research output: Contribution to journalReview article

Harvard

APA

CBE

MLA

Vancouver

Author

RIS

TY - JOUR

T1 - Graded error signals in eyeblink conditioning

AU - Rasmussen, Anders

PY - 2019/4/21

Y1 - 2019/4/21

N2 - Minimizing errors is an important aspect of learning. However, it is not enough merely to record if an error occurred. For efficient learning, information about the magnitude of errors is critical. Did my tennis swing completely miss the target or did I hit the ball, but not quite in the sweet spot? How can neurons – which have traditionally been thought of as binary units – signal the magnitude of an error? Here I review evidence that eyeblink conditioning – a basic form of motor learning – depends on graded signals from the inferior olive which guides plasticity in the cerebellum and ultimately tunes behavior. Specifically, evidence suggests that: (1)Error signals are conveyed to the cerebellum via the inferior olive; (2)Signals from the inferior olive are graded; (3)The strength of the olivary signal affects learning; (4)Cerebellar feedback influences the strength of the olivary signal. I end the review by exploring how graded error signals might explain some behavioral learning phenomena.

AB - Minimizing errors is an important aspect of learning. However, it is not enough merely to record if an error occurred. For efficient learning, information about the magnitude of errors is critical. Did my tennis swing completely miss the target or did I hit the ball, but not quite in the sweet spot? How can neurons – which have traditionally been thought of as binary units – signal the magnitude of an error? Here I review evidence that eyeblink conditioning – a basic form of motor learning – depends on graded signals from the inferior olive which guides plasticity in the cerebellum and ultimately tunes behavior. Specifically, evidence suggests that: (1)Error signals are conveyed to the cerebellum via the inferior olive; (2)Signals from the inferior olive are graded; (3)The strength of the olivary signal affects learning; (4)Cerebellar feedback influences the strength of the olivary signal. I end the review by exploring how graded error signals might explain some behavioral learning phenomena.

KW - Cerebellum

KW - Climbing fibers

KW - Error signals

KW - Eyeblink conditioning

KW - Inferior olive

KW - Learning

KW - Nucleo-Olivary pathway

KW - Plasticity

KW - Rescorla-Wagner

U2 - 10.1016/j.nlm.2019.04.011

DO - 10.1016/j.nlm.2019.04.011

M3 - Review article

JO - Neurobiology of Learning and Memory

T2 - Neurobiology of Learning and Memory

JF - Neurobiology of Learning and Memory

SN - 1074-7427

ER -