Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease

Research output: Contribution to journalArticle

Abstract

Neural transplantation can restore striatal dopaminergic neurotransmission in animal models of Parkinson's disease. It has now been shown that mesencephalic dopamine neurons, obtained from human fetuses of 8 to 9 weeks gestational age, can survive in the human brain and produce marked and sustained symptomatic relief in a patient severely affected with idiopathic Parkinson's disease. The grafts, which were implanted unilaterally into the putamen by stereotactic surgery, restored dopamine synthesis and storage in the grafted area, as assessed by positron emission tomography with 6-L-[18F]fluorodopa. This neurochemical change was accompanied by a therapeutically significant reduction in the patient's severe rigidity and bradykinesia and a marked diminuation of the fluctuations in the patient's condition during optimum medication (the "on-off" phenomenon). The clinical improvement was most marked on the side contralateral to the transplant.

Details

Authors
  • O Lindvall
  • Patrik Brundin
  • H Widner
  • S Rehncrona
  • Björn Gustavii
  • R S Frackowiak
  • K L Leenders
  • G V Sawle
  • J C Rothwell
  • C D Marsden
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • Brain, Cell Survival, Dihydroxyphenylalanine, Dopamine, Fetus, Fluorine Radioisotopes, Follow-Up Studies, Humans, Immunosuppression, Mesencephalon, Neurons, Parkinson Disease, Putamen, Tomography, Emission-Computed, Journal Article, Research Support, Non-U.S. Gov't
Original languageEnglish
Pages (from-to)574-7
JournalScience (New York, N.Y.)
Volume247
Issue number4942
Publication statusPublished - 1990 Feb 2
Publication categoryResearch
Peer-reviewedYes

Related research output

O Lindvall, Brundin, P., H Widner, Rehncrona, S., Gustavii, B., Frackowiak, R. S., Leenders, K. L., Sawle, G. V., Rothwell, J. C., Marsden, C. D. & A Björklund, 1990 Dec 7, In : Science (New York, N.Y.). 250, 4986, p. 1435

Research output: Contribution to journalLetter

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