Grainyhead-like 2 in development and cancer

Research output: Contribution to journalReview article

Abstract

Grainyhead-like 2 is a human homolog of Drosophila grainyhead. It inhibits epithelial-to-mesenchymal transition that is necessary for cell migration, and it is involved in neural tube closure, epithelial morphogenesis, and barrier formation during embryogenesis by regulation of the expression of cell junction proteins such as E-cadherin and vimentin. Cancer shares many common characters with development such as epithelial-to-mesenchymal transition. In addition to its important role in development, grainyhead-like 2 is implicated in carcinogenesis as well. However, the reports on grainyhead-like 2 in various cancers are controversial. Grainyhead-like 2 can act as either a tumor suppressor or an oncogene with the mechanisms not well elucidated. In this review, we summarized recent progress on grainyhead-like 2 in development and cancer in order to get an insight into the regulation network of grainyhead-like 2 and understand the roles of grainyhead-like 2 in various cancers.

Details

Authors
Organisations
External organisations
  • Second Military Medical University
  • Ningxia Medical University
  • Shanghai Jiao Tong University
  • Chinese University of Hong Kong
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • E-cadherin, Epithelial-to-mesenchymal transition, Metastasis, Oncogene, Tumor suppressor
Original languageEnglish
Number of pages6
JournalTumor Biology
Volume39
Issue number5
Publication statusPublished - 2017 May
Publication categoryResearch
Peer-reviewedYes