Grb10 is a dual regulator of receptor tyrosine kinase signaling

Research output: Contribution to journalReview article


title = "Grb10 is a dual regulator of receptor tyrosine kinase signaling",
abstract = "The adaptor protein Grb10 is a close homolog of Grb7 and Grb14. These proteins are characterized by an N-terminal proline-rich region, a Ras–GTPase binding domain, a PH domain, an SH2 domain and a BPS domain in between the PH and SH2 domains. Human Grb10 gene encodes three splice variants. These variants show differences in functionality. Grb10 associates with multiple proteins including tyrosine kinases in a tyrosine phosphorylation dependent or independent manner. Association with multiple proteins allows Grb10 to regulate different signaling pathways resulting in different biological consequences.",
keywords = "InsR IGF-1R FLT3 KIT PDGFR VEGFR RTK Adaptor",
author = "Kabir, {Nuzhat N.} and Kazi, {Julhash U.}",
note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Experimental Clinical Chemistry (013016010)",
year = "2014",
doi = "10.1007/s11033-014-3046-4",
language = "English",
volume = "41",
pages = "1985--1992",
journal = "Molecular Biology Reports",
issn = "0301-4851",
publisher = "Springer",
number = "4",