Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.

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Abstract

Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.

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  • Pharmacology and Toxicology
Original languageEnglish
Pages (from-to)117-120
JournalJournal of Antimicrobial Chemotherapy
Volume69
Issue number1
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes

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Related research output

Schaar, V., 2013, Medical Microbiology, Lund University.

Research output: ThesisDoctoral Thesis (compilation)

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