Growth Hormone Safety Workshop Position Paper: a critical appraisal of recombinant human growth hormone therapy in children and adults.

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@article{d82498a13818433cb4309ba3a87eba37,
title = "Growth Hormone Safety Workshop Position Paper: a critical appraisal of recombinant human growth hormone therapy in children and adults.",
abstract = "Recombinant human growth hormone (rhGH) has been in use for 30 years, and over that time its safety and efficacy in children and adults has been subject to considerable scrutiny. In 2001, a statement from the GH Research Society (GRS) concluded that 'for approved indications, GH is safe'; however, the statement highlighted a number of areas for on-going surveillance of long-term safety including; cancer risk, impact on glucose homeostasis and use of high dose pharmacological rhGH treatment. Over the intervening years, there have been a number of publications addressing the safety of rhGH with regard to mortality, cancer and cardiovascular risk and the need for longterm surveillance of the increasing number of adults who were treated with rhGH in childhood. Against this backdrop of interest in safety, the European Society of Paediatric Endocrinology (ESPE), the GRS and the Pediatric Endocrine Society (PES) convened a meeting to reappraise the safety of rhGH. The ouput of the meeting is a concise position statement.",
author = "Allen, {David B} and Philippe Backeljauw and Martin Bidlingmaier and Beverly Biller and Margaret Boguszewski and Pia Burman and Gary Butler and K Chihara and Christiansen, {Jens Sandahl} and Stefano Cianfarani and Clayton, {Peter E} and David Clemmons and Pinchas Cohen and Feyza Darendeliler and Cheri Deal and Dunger, {David P} and Erfurth, {Eva Marie} and John Fuqua and Adda Grimberg and Morey Haymond and Claire Higham and Ho, {Ken K Y} and Hoffman, {Andrew R} and Hokken-Koelega, {Anita Cs} and Gudmundur Johannsson and Anders Juul and Kopchick, {John J} and Peter Lee and Michael Pollak and Sally Radovick and Leslie Robison and Ron Rosenfeld and Ross, {Richard J} and Lars Savendahl and Paul Saenger and {Toft Sorensen}, H and Kirstine Stochholm and Strasburger, {Christian J} and Anthony Swerdlow and Thorner, {Michael O}",
year = "2015",
doi = "10.1530/EJE-15-0873",
language = "English",
journal = "European Journal of Endocrinology",
issn = "1479-683X",
publisher = "Society of the European Journal of Endocrinology",

}