Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 - Fields of Precision Nutrition

Research output: Contribution to journalArticle


Diversity in the genetic profile between individuals and specific ethnic groups affects nutrient requirements, metabolism and response to nutritional and dietary interventions. Indeed, individuals respond differently to lifestyle interventions (diet, physical activity, smoking, etc.). The sequencing of the human genome and subsequent increased knowledge regarding human genetic variation is contributing to the emergence of personalized nutrition. These advances in genetic science are raising numerous questions regarding the mode that precision nutrition can contribute solutions to emerging problems in public health, by reducing the risk and prevalence of nutrition-related diseases. Current views on personalized nutrition encompass omics technologies (nutrigenomics, transcriptomics, epigenomics, foodomics, metabolomics, metagenomics, etc.), functional food development and challenges related to legal and ethical aspects, application in clinical practice, and population scope, in terms of guidelines and epidemiological factors. In this context, precision nutrition can be considered as occurring at three levels: (1) conventional nutrition based on general guidelines for population groups by age, gender and social determinants; (2) individualized nutrition that adds phenotypic information about the person's current nutritional status (e.g. anthropometry, biochemical and metabolic analysis, physical activity, among others), and (3) genotype-directed nutrition based on rare or common gene variation. Research and appropriate translation into medical practice and dietary recommendations must be based on a solid foundation of knowledge derived from studies on nutrigenetics and nutrigenomics. A scientific society, such as the International Society of Nutrigenetics/Nutrigenomics (ISNN), internationally devoted to the study of nutrigenetics/nutrigenomics, can indeed serve the commendable roles of (1) promoting science and favoring scientific communication and (2) permanently working as a 'clearing house' to prevent disqualifying logical jumps, correct or stop unwarranted claims, and prevent the creation of unwarranted expectations in patients and in the general public. In this statement, we are focusing on the scientific aspects of disciplines covering nutrigenetics and nutrigenomics issues. Genetic screening and the ethical, legal, social and economic aspects will be dealt with in subsequent statements of the Society.


  • Lynnette R. Ferguson
  • Raffaele De Caterina
  • Hooman Allayee
  • Martin Kohlmeier
  • Chandan Prasad
  • Myung Sook Choi
  • Rui Curi
  • Daniel Antonio De Luis
  • Ángel Gil
  • Jing X. Kang
  • Ron L. Martin
  • Fermin I. Milagro
  • Carolina Ferreira Nicoletti
  • Carla Barbosa Nonino
  • Jose Maria Ordovas
  • Virginia R. Parslow
  • María P. Portillo
  • José Luis Santos
  • Charles N. Serhan
  • Artemis P. Simopoulos
  • Antonio Velázquez-Arellano
  • Maria Angeles Zulet
  • J. Alfredo Martinez
External organisations
  • University of Chieti-Pescara
  • University of Southern California
  • Kyungpook National University
  • Pontifical Catholic University of Sao Paulo
  • University of Valladolid
  • Carlos III Health Institute
  • Massachusetts General Hospital
  • Nutrigenetics Unlimited Inc.
  • IMDEA Institute
  • Pontifical Catholic University of Chile
  • Brigham and Women's Hospital / Harvard Medical School
  • National Autonomous University of Mexico
  • International Union of Nutritional Sciences (IUNS)
  • University of Auckland
  • University of North Carolina
  • Louisiana State University
  • Tufts University
  • Center for Genetics, Nutrition and Health
  • University of Navarra
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Nutrition and Dietetics


  • Genetic tests, Health and disease, Nutrigenetics, Nutrigenomics, Omics, Precision nutrition
Original languageEnglish
Pages (from-to)12-27
Number of pages16
JournalJournal of Nutrigenetics and Nutrigenomics
Issue number1
Publication statusPublished - 2016 Jun 1
Publication categoryResearch