HAMLET; a novel tool to identify apoptotic pathways in tumor cells.

Research output: Chapter in Book/Report/Conference proceedingBook chapter

Standard

HAMLET; a novel tool to identify apoptotic pathways in tumor cells. / Düringer, Caroline; Hallgren, Oskar; Gustafsson, Lotta; Pettersson, Jenny; Mossberg, Anki; Manolov, Taras; Svanborg, Catharina.

Application of apoptosis to cancer treatment.. ed. / Sluyser Mels. Springer, 2005. p. 223-245.

Research output: Chapter in Book/Report/Conference proceedingBook chapter

Harvard

Düringer, C, Hallgren, O, Gustafsson, L, Pettersson, J, Mossberg, A, Manolov, T & Svanborg, C 2005, HAMLET; a novel tool to identify apoptotic pathways in tumor cells. in S Mels (ed.), Application of apoptosis to cancer treatment.. Springer, pp. 223-245. https://doi.org/10.1007/1-4020-3302-8_10

APA

Düringer, C., Hallgren, O., Gustafsson, L., Pettersson, J., Mossberg, A., Manolov, T., & Svanborg, C. (2005). HAMLET; a novel tool to identify apoptotic pathways in tumor cells. In S. Mels (Ed.), Application of apoptosis to cancer treatment. (pp. 223-245). Springer. https://doi.org/10.1007/1-4020-3302-8_10

CBE

Düringer C, Hallgren O, Gustafsson L, Pettersson J, Mossberg A, Manolov T, Svanborg C. 2005. HAMLET; a novel tool to identify apoptotic pathways in tumor cells. Mels S, editor. In Application of apoptosis to cancer treatment.. Springer. pp. 223-245. https://doi.org/10.1007/1-4020-3302-8_10

MLA

Düringer, Caroline et al. "HAMLET; a novel tool to identify apoptotic pathways in tumor cells.". Mels, Sluyser (ed.). Application of apoptosis to cancer treatment.. Springer. 2005, 223-245. https://doi.org/10.1007/1-4020-3302-8_10

Vancouver

Düringer C, Hallgren O, Gustafsson L, Pettersson J, Mossberg A, Manolov T et al. HAMLET; a novel tool to identify apoptotic pathways in tumor cells. In Mels S, editor, Application of apoptosis to cancer treatment.. Springer. 2005. p. 223-245 https://doi.org/10.1007/1-4020-3302-8_10

Author

Düringer, Caroline ; Hallgren, Oskar ; Gustafsson, Lotta ; Pettersson, Jenny ; Mossberg, Anki ; Manolov, Taras ; Svanborg, Catharina. / HAMLET; a novel tool to identify apoptotic pathways in tumor cells. Application of apoptosis to cancer treatment.. editor / Sluyser Mels. Springer, 2005. pp. 223-245

RIS

TY - CHAP

T1 - HAMLET; a novel tool to identify apoptotic pathways in tumor cells.

AU - Düringer, Caroline

AU - Hallgren, Oskar

AU - Gustafsson, Lotta

AU - Pettersson, Jenny

AU - Mossberg, Anki

AU - Manolov, Taras

AU - Svanborg, Catharina

PY - 2005

Y1 - 2005

N2 - Tumor cells often carry mutations in genes that control cell survival, and become resistant to signals that trigger cell death. Yet, some cell death pathways remain intact in tumor cells. If identified, these pathways might be exploited to selectively remove tumor cells. HAMLET (human α-lactalbumin made lethal to tumor cells) is a protein-lipid complex derived from human milk that activates cell death programs in tumor cells but not in healthy differentiated cells. We use HAMLET as a tool to identify apoptosis and apoptosis-like cell death mechanisms in tumor cells and to understand if these mechanisms differ between tumor and healthy cells. HAMLET interacts with the cell surface, translocates into the cytoplasm and accumulates in cell nuclei, where it disrupts the chromatin. Recent in vivo studies have shown that HAMLET maintains the tumoricidal activity in glioblastoma, papilloma and bladder cancer models, with no significant side effects. The results suggest that HAMLET should be explored as a new therapeutic agent with selectivity for the tumor and with little toxicity for adjacent healthy tissue. Such therapies are a much-needed complement to conventional treatments, to reduce the side effects and improve the selectivity.

AB - Tumor cells often carry mutations in genes that control cell survival, and become resistant to signals that trigger cell death. Yet, some cell death pathways remain intact in tumor cells. If identified, these pathways might be exploited to selectively remove tumor cells. HAMLET (human α-lactalbumin made lethal to tumor cells) is a protein-lipid complex derived from human milk that activates cell death programs in tumor cells but not in healthy differentiated cells. We use HAMLET as a tool to identify apoptosis and apoptosis-like cell death mechanisms in tumor cells and to understand if these mechanisms differ between tumor and healthy cells. HAMLET interacts with the cell surface, translocates into the cytoplasm and accumulates in cell nuclei, where it disrupts the chromatin. Recent in vivo studies have shown that HAMLET maintains the tumoricidal activity in glioblastoma, papilloma and bladder cancer models, with no significant side effects. The results suggest that HAMLET should be explored as a new therapeutic agent with selectivity for the tumor and with little toxicity for adjacent healthy tissue. Such therapies are a much-needed complement to conventional treatments, to reduce the side effects and improve the selectivity.

KW - HAMLET

KW - lactalbumin

KW - cancer

KW - apoptosis

KW - apoptosis-like

KW - programmed cell death

KW - alpha- histone

KW - p53

KW - bcl-2

KW - caspase

KW - glioblastoma

KW - HPV

U2 - 10.1007/1-4020-3302-8_10

DO - 10.1007/1-4020-3302-8_10

M3 - Book chapter

SN - 978-1-4020-3303-2

SP - 223

EP - 245

BT - Application of apoptosis to cancer treatment.

A2 - Mels, Sluyser

PB - Springer

ER -