HAMLET kills tumor cells by apoptosis: Structure, cellular mechanisms, and therapy

Research output: Contribution to journalArticle

Abstract

New cancer treatments should aim to destroy tumor cells without disturbing normal tissue. HAMLET (human a-lactalbumin made lethal to tumor cells) offers a new molecular approach to solving this problem, because it induces apoptosis in tumor cells but leaves normal differentiated cells unaffected. After partial unfolding and binding to oleic acid, α-lactalbumin forms the HAMLET complex, which enters tumor cells and freezes their metabolic machinery. The cells proceed to fragment their DNA, and they disintegrate with apoptosis-like characteristics. HAMLET kills a wide range of malignant cells in vitro and maintains this activity in vivo in patients with skin papillomas. In addition, HAMLET has striking effects on human glioblastomas in a rat xenograft model. After convection-enhanced delivery, HAMLET diffuses throughout the brain, selectively killing tumor cells and controlling tumor progression without apparent tissue toxicity. HAMLET thus shows great promise as a new therapeutic with the advantage of selectivity for tumor cells and lack of toxicity.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Nutrition and Dietetics

Keywords

  • lactalbumin, human milk, tumor, apoptosis, protein folding
Original languageEnglish
Pages (from-to)1299-1303
JournalJournal of Nutrition
Volume135
Issue number5
Publication statusPublished - 2005
Publication categoryResearch
Peer-reviewedYes

Related projects

Lotta Gustafsson

2000/09/012008/09/01

Project: DissertationInternational collaboration, National collaboration, Teaching, Collaboration with industry

View all (1)