Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome–A SYSDIET Sub-Study

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@article{f6d3e570d49e4af5ad21ad4f26e42c5a,
title = "Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome–A SYSDIET Sub-Study",
abstract = "Scope: To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with metabolic syndrome. Methods and results: Subjects with metabolic syndrome undergo a 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants are included. PBMCs are obtained before and after intervention and total RNA is subjected to global transcriptome analysis. 1302 probe sets are differentially expressed between the diet groups (p-value < 0.05). Twenty-five of these are significantly regulated (FDR q-value < 0.25) and are mainly involved in mitochondrial function, cell growth, and cell adhesion. The list of 1302 regulated probe sets is subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response, and cell cycle are downregulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors, including NFR1, NFR2, and NF-κB, are downregulated in the healthy Nordic diet group. Conclusion: These results suggest that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation.",
keywords = "gene-expression, healthy Nordic diet, metabolic syndrome, peripheral blood mononuclear cells, transcriptome",
author = "Myhrstad, {Mari C.W.} and {de Mello}, {Vanessa D.} and Ingrid Dahlman and Marjukka Kolehmainen and Jussi Paananen and Amanda Rundblad and Carsten Carlberg and Olstad, {Ole Kristoffer} and Jussi Pihlajam{\"a}ki and Holven, {Kirsten B.} and Kjeld Hermansen and Dragsted, {Lars O.} and Ingibj{\"o}rg Gunnarsdottir and Lieselotte Cloetens and Storm, {Matilda Ulmius} and Bj{\"o}rn {\AA}kesson and Fredrik Rosqvist and Janne Hukkanen and Herzig, {Karl Heinz} and Ulf Ris{\'e}rus and Inga Thorsdottir and Poutanen, {Kaisa S.} and Savolainen, {Markku J.} and Ursula Schwab and Peter Arner and Matti Uusitupa and Ulven, {Stine M.}",
year = "2019",
month = "4",
day = "9",
doi = "10.1002/mnfr.201801405",
language = "English",
journal = "Molecular Nutrition and Food Research",
issn = "1613-4133",
publisher = "John Wiley & Sons",

}