Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome–A SYSDIET Sub-Study

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Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome–A SYSDIET Sub-Study. / Myhrstad, Mari C.W.; de Mello, Vanessa D.; Dahlman, Ingrid; Kolehmainen, Marjukka; Paananen, Jussi; Rundblad, Amanda; Carlberg, Carsten; Olstad, Ole Kristoffer; Pihlajamäki, Jussi; Holven, Kirsten B.; Hermansen, Kjeld; Dragsted, Lars O.; Gunnarsdottir, Ingibjörg; Cloetens, Lieselotte; Storm, Matilda Ulmius; Åkesson, Björn; Rosqvist, Fredrik; Hukkanen, Janne; Herzig, Karl Heinz; Risérus, Ulf; Thorsdottir, Inga; Poutanen, Kaisa S.; Savolainen, Markku J.; Schwab, Ursula; Arner, Peter; Uusitupa, Matti; Ulven, Stine M.

In: Molecular Nutrition and Food Research, 09.04.2019.

Research output: Contribution to journalArticle

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Myhrstad, MCW, de Mello, VD, Dahlman, I, Kolehmainen, M, Paananen, J, Rundblad, A, Carlberg, C, Olstad, OK, Pihlajamäki, J, Holven, KB, Hermansen, K, Dragsted, LO, Gunnarsdottir, I, Cloetens, L, Storm, MU, Åkesson, B, Rosqvist, F, Hukkanen, J, Herzig, KH, Risérus, U, Thorsdottir, I, Poutanen, KS, Savolainen, MJ, Schwab, U, Arner, P, Uusitupa, M & Ulven, SM 2019, 'Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome–A SYSDIET Sub-Study', Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.201801405

APA

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Myhrstad MCW, de Mello VD, Dahlman I, Kolehmainen M, Paananen J, Rundblad A, Carlberg C, Olstad OK, Pihlajamäki J, Holven KB, Hermansen K, Dragsted LO, Gunnarsdottir I, Cloetens L, Storm MU, Åkesson B, Rosqvist F, Hukkanen J, Herzig KH, Risérus U, Thorsdottir I, Poutanen KS, Savolainen MJ, Schwab U, Arner P, Uusitupa M, Ulven SM. 2019. Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome–A SYSDIET Sub-Study. Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.201801405

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Myhrstad, Mari C.W. ; de Mello, Vanessa D. ; Dahlman, Ingrid ; Kolehmainen, Marjukka ; Paananen, Jussi ; Rundblad, Amanda ; Carlberg, Carsten ; Olstad, Ole Kristoffer ; Pihlajamäki, Jussi ; Holven, Kirsten B. ; Hermansen, Kjeld ; Dragsted, Lars O. ; Gunnarsdottir, Ingibjörg ; Cloetens, Lieselotte ; Storm, Matilda Ulmius ; Åkesson, Björn ; Rosqvist, Fredrik ; Hukkanen, Janne ; Herzig, Karl Heinz ; Risérus, Ulf ; Thorsdottir, Inga ; Poutanen, Kaisa S. ; Savolainen, Markku J. ; Schwab, Ursula ; Arner, Peter ; Uusitupa, Matti ; Ulven, Stine M. / Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome–A SYSDIET Sub-Study. In: Molecular Nutrition and Food Research. 2019.

RIS

TY - JOUR

T1 - Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome–A SYSDIET Sub-Study

AU - Myhrstad, Mari C.W.

AU - de Mello, Vanessa D.

AU - Dahlman, Ingrid

AU - Kolehmainen, Marjukka

AU - Paananen, Jussi

AU - Rundblad, Amanda

AU - Carlberg, Carsten

AU - Olstad, Ole Kristoffer

AU - Pihlajamäki, Jussi

AU - Holven, Kirsten B.

AU - Hermansen, Kjeld

AU - Dragsted, Lars O.

AU - Gunnarsdottir, Ingibjörg

AU - Cloetens, Lieselotte

AU - Storm, Matilda Ulmius

AU - Åkesson, Björn

AU - Rosqvist, Fredrik

AU - Hukkanen, Janne

AU - Herzig, Karl Heinz

AU - Risérus, Ulf

AU - Thorsdottir, Inga

AU - Poutanen, Kaisa S.

AU - Savolainen, Markku J.

AU - Schwab, Ursula

AU - Arner, Peter

AU - Uusitupa, Matti

AU - Ulven, Stine M.

PY - 2019/4/9

Y1 - 2019/4/9

N2 - Scope: To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with metabolic syndrome. Methods and results: Subjects with metabolic syndrome undergo a 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants are included. PBMCs are obtained before and after intervention and total RNA is subjected to global transcriptome analysis. 1302 probe sets are differentially expressed between the diet groups (p-value < 0.05). Twenty-five of these are significantly regulated (FDR q-value < 0.25) and are mainly involved in mitochondrial function, cell growth, and cell adhesion. The list of 1302 regulated probe sets is subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response, and cell cycle are downregulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors, including NFR1, NFR2, and NF-κB, are downregulated in the healthy Nordic diet group. Conclusion: These results suggest that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation.

AB - Scope: To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with metabolic syndrome. Methods and results: Subjects with metabolic syndrome undergo a 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants are included. PBMCs are obtained before and after intervention and total RNA is subjected to global transcriptome analysis. 1302 probe sets are differentially expressed between the diet groups (p-value < 0.05). Twenty-five of these are significantly regulated (FDR q-value < 0.25) and are mainly involved in mitochondrial function, cell growth, and cell adhesion. The list of 1302 regulated probe sets is subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response, and cell cycle are downregulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors, including NFR1, NFR2, and NF-κB, are downregulated in the healthy Nordic diet group. Conclusion: These results suggest that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation.

KW - gene-expression

KW - healthy Nordic diet

KW - metabolic syndrome

KW - peripheral blood mononuclear cells

KW - transcriptome

U2 - 10.1002/mnfr.201801405

DO - 10.1002/mnfr.201801405

M3 - Article

JO - Molecular Nutrition and Food Research

T2 - Molecular Nutrition and Food Research

JF - Molecular Nutrition and Food Research

SN - 1613-4133

M1 - 1801405

ER -