Helicobacter pylori : Is it Transmitted Through Faecal-oral or Oral-oral Route?

Research output: Contribution to journalArticle


The association of Helicobacter pylori with gastroduodenal diseases is well established. The mode of transmission of the organism is still unclear, although the faecal-oral route has been proposed. H. pylori has been detected in gastric antrum, dental plaques, faeces and water. In the light of these studies we attempted to detect H. pylori in antral biopsies, dental plaques, and stool specimens of patients who were suffering from upper GI complaints. These patients resided in Mumbai city, India. Clinical specimens from different sources were subjected to RUT, Culture, Histopathology and Polymerase chain reaction (PCR). We found H. pylori in antral biopsies and faeces by culture and PCR but absent in dental plaques. Therefore, faecal-oral is the possible route of transmission of this bacterium. Dental plaque may not be a permanent reservoir of this bacterium because this organism needs strict microaerophilic conditions to survive.


  • Rupa Mulchandani
  • Hans-Olof Nilsson
  • Torkel Wadström
  • B. R. Joshi
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology in the medical area


  • Helicobacter pylori, PCR, faeces, HPU, VacA, CagA
Original languageEnglish
Pages (from-to)2429-2438
JournalJournal of Pure and Applied Microbiology
Issue number3
Publication statusPublished - 2013
Publication categoryResearch