Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging

Research output: Contribution to journalArticle

Abstract

The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor activity-directed affinity tagging. The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori.

Details

Authors
  • D Ilver
  • A Arnqvist
  • J Ogren
  • Inga-Maria Frick
  • D Kersulyte
  • E T Incecik
  • D E Berg
  • A Covacci
  • L Engstrand
  • T Boren
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Infectious Medicine
Original languageEnglish
Pages (from-to)373-377
JournalScience
Volume279
Issue number5349
Publication statusPublished - 1998
Publication categoryResearch
Peer-reviewedYes