Hematopoietic stem cells: the paradigmatic tissue-specific stem cell

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Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. / Bryder, David; Rossi, Derrick J; Weissman, Irving L.

In: American Journal of Pathology, Vol. 169, No. 2, 2006, p. 338-346.

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Bryder, David ; Rossi, Derrick J ; Weissman, Irving L. / Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. In: American Journal of Pathology. 2006 ; Vol. 169, No. 2. pp. 338-346.

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TY - JOUR

T1 - Hematopoietic stem cells: the paradigmatic tissue-specific stem cell

AU - Bryder, David

AU - Rossi, Derrick J

AU - Weissman, Irving L

PY - 2006

Y1 - 2006

N2 - The recent prospective isolation of a wide variety of somatically derived stem cells has affirmed the notion that homeostatic maintenance of most tissues and organs is mediated by tissue-specific stem and progenitor cells and fueled enthusiasm for the use of such cells in strategies aimed at repairing or replacing damaged, diseased, or genetically deficient tissues and organs. Hematopoietic stem cells (HSCs) are arguably the most well-characterized tissue-specific stem cell, with decades of basic research and clinical application providing not only a profound understanding of the principles of stem cell biology, but also of its potential pitfalls. It is our belief that emerging stem cell fields can benefit greatly from an understanding of the lessons learned from the study of HSCs. In this review we discuss some general concepts regarding stem cell biology learned from the study of HSCs with a highlight on recent work pertaining to emerging topics of interest for stem cell biology.

AB - The recent prospective isolation of a wide variety of somatically derived stem cells has affirmed the notion that homeostatic maintenance of most tissues and organs is mediated by tissue-specific stem and progenitor cells and fueled enthusiasm for the use of such cells in strategies aimed at repairing or replacing damaged, diseased, or genetically deficient tissues and organs. Hematopoietic stem cells (HSCs) are arguably the most well-characterized tissue-specific stem cell, with decades of basic research and clinical application providing not only a profound understanding of the principles of stem cell biology, but also of its potential pitfalls. It is our belief that emerging stem cell fields can benefit greatly from an understanding of the lessons learned from the study of HSCs. In this review we discuss some general concepts regarding stem cell biology learned from the study of HSCs with a highlight on recent work pertaining to emerging topics of interest for stem cell biology.

U2 - 10.2353/ajpath.2006.060312

DO - 10.2353/ajpath.2006.060312

M3 - Article

VL - 169

SP - 338

EP - 346

JO - American Journal of Pathology

T2 - American Journal of Pathology

JF - American Journal of Pathology

SN - 1525-2191

IS - 2

ER -