Heme b (protoheme IX) is a precursor of heme a and heme d in Bacillus subtilis

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Abstract

Bacillus subtilis can synthesise cytochromes containing a-, b-, c- and d-type heme. The biosynthetic pathways of these heme prosthetic groups were investigated by using strains blocked in uroporphyrinogen III synthesis from porphobilinogen or in heme b (protoheme IX) synthesis from uroporphyrinogen III. The results strongly suggest that heme a and heme d are both synthesised from heme b (protoheme IX). They also indicate that B. subtilis contains a novel ferrochelatase involved in the synthesis of siroheme

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Subject classification (UKÄ) – MANDATORY

  • Microbiology
Original languageEnglish
Pages (from-to)121-126
JournalFEMS Microbiology Letters
Volume107
Issue number1
Publication statusPublished - 1993
Publication categoryResearch
Peer-reviewedYes