Hemophilia and prophylaxis.

Research output: Contribution to journalReview article

Abstract

Clinical experience over decades and numerous retrospective and, recently, also prospective studies clearly demonstrate that prophylactic treatment, albeit much more expensive, is superior to on-demand treatment regardless of whether the outcome is number of joint- or life-threatening bleeds or arthropathy optimal prophylactic treatment should be started early (primary prophylaxis) but various opinions exist on the model. The optimal model should be to individualize prophylaxis taking into account the bleeding phenotype and the individual susceptibility to arthropathy and further develop monitoring by global coagulation assays and pharmacokinetic parameters. This review covers proof of concept of primary prophylaxis in children, comparisons between prophylaxis and on demand treatment, and future trends of prophylactic treatment of hemophilia. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pediatrics
  • Hematology
Original languageEnglish
Pages (from-to)S23-S26
JournalPediatric Blood & Cancer
Volume60
Issue numberSuppl. S1
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes