Heparan sulphate proteoglycans: the sweet side of development.

Research output: Contribution to journalReview article

Abstract

Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.

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Authors
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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Basic Medicine

Keywords

  • Glycosaminoglycans: biosynthesis, Gene Expression Regulation, Animals, N.I.H., U.S. Gov't, P.H.S., Signal Transduction, Non-U.S. Gov't, Research Support, Extramural, Heparan Sulfate Proteoglycan: genetics, Heparan Sulfate Proteoglycan: physiology, Humans, Mutation
Original languageEnglish
Pages (from-to)530-541
JournalNature Reviews. Molecular Cell Biology
Volume6
Issue number7
Publication statusPublished - 2005
Publication categoryResearch
Peer-reviewedYes