Hepatic lymph nodes as a follow-up factor in primary biliary cirrhosis: An ultrasound study

Research output: Contribution to journalArticle

Abstract

Background: The aim of this study was to investigate whether changes in lymph node size in the hepatoduodenal ligament reflect changes in biochemical and histologic markers of cholestasis, hepatocellular damage, and humoral immunoreactivity in patients with primary biliary cirrhosis (PBC). Methods: Twenty-three consecutive patients were examined with repeated liver biopsies, laboratory tests, and ultrasonographic examinations of the hepatoduodenal ligament. The effect of treatment with ursodeoxycholic acid (UDCA) on these factors was also studied. Results: A correlation was found between changes in lymph node size and changes in markers of hepatocellular damage, cholestasis, and humoral immunoreactivity and also with intralobular inflammation. In the UDCA-treated patients the node size decreased slightly during 2 years of treatment, whereas it was unchanged in the control group (p = 0.0528). Conclusions: Changes in the size of the lymph nodes in the hepatoduodenal ligament may reflect inflammation and cholestasis in PBC and thus be a valuable indicator in the follow-up of patients with this disease.

Details

Authors
  • K. Lyttkens
  • H. Prytz
  • L. Forsberg
  • I. Hägerstrand
External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Gastroenterology and Hepatology

Keywords

  • Cholestasis, Hepatocellular damage, Humoral immunoreactivity, Intralobular inflammation, Ursodeoxycholic acid
Original languageEnglish
Pages (from-to)1036-1040
Number of pages5
JournalScandinavian Journal of Gastroenterology
Volume30
Issue number10
Publication statusPublished - 1995 Jan 1
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes