Heritability of cilioretinal arteries: a twin study

Research output: Contribution to journalArticle

Abstract

Abstract PURPOSE: To determine whether the presence of one or more cilioretinal arteries, a distinct element of the pattern of fundus vessels, is genetically programmed, influenced by environmental factors, or the result of random mechanisms of vascular development. METHODS: The fundi of 112 pairs of healthy monozygotic and dizygotic twins were examined using digital fundus photography and visual assessment of grayscale fundus photographs and color transparencies to detect the presence of cilioretinal arteries. RESULTS: Cilioretinal arteries were present in 45.1% of participants and 28.8% of eyes. The majority of cilioretinal arteries, 88.2%, were located temporally, and 11.8% were located nasally. Monozygotic twins had higher concordance rates for cilioretinal arteries than dizygotic twins. Tetrachoric correlations and Mantel-Haenszel odds ratios demonstrated statistically significant evidence of a genetic effect underlying the presence of cilioretinal arteries (P < 0.01). Statistical analysis supported the hypothesis that additive genetic factors influenced the presence of cilioretinal arteries with a heritability of 71.4%, the remaining variance being attributable to nonshared or random environmental factors. CONCLUSIONS: The presence or absence of one or more cilioretinal arteries in healthy persons is markedly influenced by genetic factors.

Details

Authors
  • Nina Charlotte Bille Brahe Taarnhøj
  • Inger Christine Munch
  • Kirsten Ohm Kyvik
  • Birgit Sander
  • Line Kessel
  • Thorkild I A Sørensen
  • Jesper Leth Hougaard
  • Michael Larsen
External organisations
  • University of Southern Denmark
  • Herlev Hospital
  • University of Copenhagen
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Ophthalmology
Original languageEnglish
Pages (from-to)3850-3854
JournalInvestigative Ophthalmology & Visual Science
Volume46
Issue number10
Publication statusPublished - 2005 Oct
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes