Heritability of cilioretinal arteries: a twin study

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Heritability of cilioretinal arteries: a twin study. / Taarnhøj, Nina Charlotte Bille Brahe; Munch, Inger Christine; Kyvik, Kirsten Ohm; Sander, Birgit; Kessel, Line; Sørensen, Thorkild I A; Hougaard, Jesper Leth; Larsen, Michael.

In: Investigative Ophthalmology & Visual Science, Vol. 46, No. 10, 10.2005, p. 3850-3854.

Research output: Contribution to journalArticle

Harvard

Taarnhøj, NCBB, Munch, IC, Kyvik, KO, Sander, B, Kessel, L, Sørensen, TIA, Hougaard, JL & Larsen, M 2005, 'Heritability of cilioretinal arteries: a twin study', Investigative Ophthalmology & Visual Science, vol. 46, no. 10, pp. 3850-3854. https://doi.org/10.1167/iovs.05-0177

APA

Taarnhøj, N. C. B. B., Munch, I. C., Kyvik, K. O., Sander, B., Kessel, L., Sørensen, T. I. A., ... Larsen, M. (2005). Heritability of cilioretinal arteries: a twin study. Investigative Ophthalmology & Visual Science, 46(10), 3850-3854. https://doi.org/10.1167/iovs.05-0177

CBE

Taarnhøj NCBB, Munch IC, Kyvik KO, Sander B, Kessel L, Sørensen TIA, Hougaard JL, Larsen M. 2005. Heritability of cilioretinal arteries: a twin study. Investigative Ophthalmology & Visual Science. 46(10):3850-3854. https://doi.org/10.1167/iovs.05-0177

MLA

Vancouver

Taarnhøj NCBB, Munch IC, Kyvik KO, Sander B, Kessel L, Sørensen TIA et al. Heritability of cilioretinal arteries: a twin study. Investigative Ophthalmology & Visual Science. 2005 Oct;46(10):3850-3854. https://doi.org/10.1167/iovs.05-0177

Author

Taarnhøj, Nina Charlotte Bille Brahe ; Munch, Inger Christine ; Kyvik, Kirsten Ohm ; Sander, Birgit ; Kessel, Line ; Sørensen, Thorkild I A ; Hougaard, Jesper Leth ; Larsen, Michael. / Heritability of cilioretinal arteries: a twin study. In: Investigative Ophthalmology & Visual Science. 2005 ; Vol. 46, No. 10. pp. 3850-3854.

RIS

TY - JOUR

T1 - Heritability of cilioretinal arteries: a twin study

AU - Taarnhøj, Nina Charlotte Bille Brahe

AU - Munch, Inger Christine

AU - Kyvik, Kirsten Ohm

AU - Sander, Birgit

AU - Kessel, Line

AU - Sørensen, Thorkild I A

AU - Hougaard, Jesper Leth

AU - Larsen, Michael

PY - 2005/10

Y1 - 2005/10

N2 - Abstract PURPOSE: To determine whether the presence of one or more cilioretinal arteries, a distinct element of the pattern of fundus vessels, is genetically programmed, influenced by environmental factors, or the result of random mechanisms of vascular development. METHODS: The fundi of 112 pairs of healthy monozygotic and dizygotic twins were examined using digital fundus photography and visual assessment of grayscale fundus photographs and color transparencies to detect the presence of cilioretinal arteries. RESULTS: Cilioretinal arteries were present in 45.1% of participants and 28.8% of eyes. The majority of cilioretinal arteries, 88.2%, were located temporally, and 11.8% were located nasally. Monozygotic twins had higher concordance rates for cilioretinal arteries than dizygotic twins. Tetrachoric correlations and Mantel-Haenszel odds ratios demonstrated statistically significant evidence of a genetic effect underlying the presence of cilioretinal arteries (P < 0.01). Statistical analysis supported the hypothesis that additive genetic factors influenced the presence of cilioretinal arteries with a heritability of 71.4%, the remaining variance being attributable to nonshared or random environmental factors. CONCLUSIONS: The presence or absence of one or more cilioretinal arteries in healthy persons is markedly influenced by genetic factors.

AB - Abstract PURPOSE: To determine whether the presence of one or more cilioretinal arteries, a distinct element of the pattern of fundus vessels, is genetically programmed, influenced by environmental factors, or the result of random mechanisms of vascular development. METHODS: The fundi of 112 pairs of healthy monozygotic and dizygotic twins were examined using digital fundus photography and visual assessment of grayscale fundus photographs and color transparencies to detect the presence of cilioretinal arteries. RESULTS: Cilioretinal arteries were present in 45.1% of participants and 28.8% of eyes. The majority of cilioretinal arteries, 88.2%, were located temporally, and 11.8% were located nasally. Monozygotic twins had higher concordance rates for cilioretinal arteries than dizygotic twins. Tetrachoric correlations and Mantel-Haenszel odds ratios demonstrated statistically significant evidence of a genetic effect underlying the presence of cilioretinal arteries (P < 0.01). Statistical analysis supported the hypothesis that additive genetic factors influenced the presence of cilioretinal arteries with a heritability of 71.4%, the remaining variance being attributable to nonshared or random environmental factors. CONCLUSIONS: The presence or absence of one or more cilioretinal arteries in healthy persons is markedly influenced by genetic factors.

U2 - 10.1167/iovs.05-0177

DO - 10.1167/iovs.05-0177

M3 - Article

VL - 46

SP - 3850

EP - 3854

JO - Investigative Ophthalmology & Visual Science

JF - Investigative Ophthalmology & Visual Science

SN - 1552-5783

IS - 10

ER -