Heritability of retinal vascular fractals: A twin study

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Heritability of retinal vascular fractals : A twin study. / Vergmann, Anna Stage; Broe, Rebecca; Kessel, Line; Hougaard, Jesper Leth; Möller Christensen, Sören, Sören; Kyvik, Kirsten Ohm; Larsen, Michael; Munch, Inger Christine; Grauslund, Jakob.

In: Investigative Ophthalmology and Visual Science, Vol. 58, No. 10, 2017, p. 3997-4002.

Research output: Contribution to journalArticle

Harvard

Vergmann, AS, Broe, R, Kessel, L, Hougaard, JL, Möller Christensen, Sören, S, Kyvik, KO, Larsen, M, Munch, IC & Grauslund, J 2017, 'Heritability of retinal vascular fractals: A twin study', Investigative Ophthalmology and Visual Science, vol. 58, no. 10, pp. 3997-4002. https://doi.org/10.1167/iovs.17-22072

APA

Vergmann, A. S., Broe, R., Kessel, L., Hougaard, J. L., Möller Christensen, Sören, S., Kyvik, K. O., ... Grauslund, J. (2017). Heritability of retinal vascular fractals: A twin study. Investigative Ophthalmology and Visual Science, 58(10), 3997-4002. https://doi.org/10.1167/iovs.17-22072

CBE

Vergmann AS, Broe R, Kessel L, Hougaard JL, Möller Christensen, Sören S, Kyvik KO, Larsen M, Munch IC, Grauslund J. 2017. Heritability of retinal vascular fractals: A twin study. Investigative Ophthalmology and Visual Science. 58(10):3997-4002. https://doi.org/10.1167/iovs.17-22072

MLA

Vancouver

Vergmann AS, Broe R, Kessel L, Hougaard JL, Möller Christensen, Sören S, Kyvik KO et al. Heritability of retinal vascular fractals: A twin study. Investigative Ophthalmology and Visual Science. 2017;58(10):3997-4002. https://doi.org/10.1167/iovs.17-22072

Author

Vergmann, Anna Stage ; Broe, Rebecca ; Kessel, Line ; Hougaard, Jesper Leth ; Möller Christensen, Sören, Sören ; Kyvik, Kirsten Ohm ; Larsen, Michael ; Munch, Inger Christine ; Grauslund, Jakob. / Heritability of retinal vascular fractals : A twin study. In: Investigative Ophthalmology and Visual Science. 2017 ; Vol. 58, No. 10. pp. 3997-4002.

RIS

TY - JOUR

T1 - Heritability of retinal vascular fractals

T2 - Investigative Ophthalmology & Visual Science

AU - Vergmann, Anna Stage

AU - Broe, Rebecca

AU - Kessel, Line

AU - Hougaard, Jesper Leth

AU - Möller Christensen, Sören, Sören

AU - Kyvik, Kirsten Ohm

AU - Larsen, Michael

AU - Munch, Inger Christine

AU - Grauslund, Jakob

PY - 2017

Y1 - 2017

N2 - PURPOSE. To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension. METHODS. This was a cross-sectional study of 50 monozygotic and 49 dizygotic, same-sex twin pairs aged 20 to 46 years. In 50º, disc-centered fundus photographs, the retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficients. Falconer’s formula and quantitative genetic models were used to determine the genetic component of variation. RESULTS. The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, P = 0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, P = 0.0002) in monozygotic twins than in dizygotic twins (0.108, P = 0.46), corresponding to a heritability h2 for the fractal dimension of 0.79. In quantitative genetic models, dominant genetic effects explained 54% of the variation and 46% was individually environmentally determined. CONCLUSIONS. In young adult twins, the branching pattern of the retinal vessels demonstrated a higher structural similarity in monozygotic than in dizygotic twin pairs. The retinal vascular fractal dimension was mainly determined by genetic factors, which accounted for 54% of the variation. The genetically predetermination of the retinal vasculature may affect the retinal response to potential vascular disease in later life.

AB - PURPOSE. To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension. METHODS. This was a cross-sectional study of 50 monozygotic and 49 dizygotic, same-sex twin pairs aged 20 to 46 years. In 50º, disc-centered fundus photographs, the retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficients. Falconer’s formula and quantitative genetic models were used to determine the genetic component of variation. RESULTS. The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, P = 0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, P = 0.0002) in monozygotic twins than in dizygotic twins (0.108, P = 0.46), corresponding to a heritability h2 for the fractal dimension of 0.79. In quantitative genetic models, dominant genetic effects explained 54% of the variation and 46% was individually environmentally determined. CONCLUSIONS. In young adult twins, the branching pattern of the retinal vessels demonstrated a higher structural similarity in monozygotic than in dizygotic twin pairs. The retinal vascular fractal dimension was mainly determined by genetic factors, which accounted for 54% of the variation. The genetically predetermination of the retinal vasculature may affect the retinal response to potential vascular disease in later life.

KW - Dizogotic

KW - Heredity

KW - Monozygotic

KW - Retinal vascular fractal dimension

KW - Twin

UR - http://www.scopus.com/inward/record.url?scp=85027374014&partnerID=8YFLogxK

U2 - 10.1167/iovs.17-22072

DO - 10.1167/iovs.17-22072

M3 - Article

VL - 58

SP - 3997

EP - 4002

JO - Investigative Ophthalmology & Visual Science

JF - Investigative Ophthalmology & Visual Science

SN - 1552-5783

IS - 10

ER -