High circulating levels of midregional proenkephalin A predict vascular dementia: a population-based prospective study

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@article{7a722090bf22402e88eff92f09ba14f8,
title = "High circulating levels of midregional proenkephalin A predict vascular dementia: a population-based prospective study",
abstract = "Midregional Pro-enkephalin A (MR-PENK A) and N-terminal Protachykinin A (NT-PTA) have been associated with vascular dementia. However, the longitudinal relationship between these biomarkers and incident dementia has not been fully investigated. In the population-based Malm{\"o} Preventive Project, circulating levels of MR-PENK A and NT-PTA were determined in a random sample of 5,323 study participants (mean age: 69 ± 6 years) who were followed-up over a period of 4.6 ± 1.6 years. The study sample included 369 patients (7{\%}) who were diagnosed in the same period with dementia. We analyzed relationship of MR-PENK A and NT-PTA with the risk of developing dementia by using multivariable-adjusted Cox regression models adjusted for traditional risk factors. Increased plasma levels of MR-PENK A were associated with higher risk of incident vascular dementia whereas no associations were found with all-cause or Alzheimer dementia. The risk of vascular dementia was mainly conferred by the highest quartile of MR-PENK as compared with lower quartiles. Elevated levels of NT-PTA yielded significant association with all-cause dementia or dementia subtypes. Elevated plasma concentration of MR-PENK A independently predicts vascular dementia in the general population. MR-PENK A may be used as an additional tool for identifying vascular subtype in ambiguous dementia cases.",
keywords = "BIOMARKERS",
author = "H Holm and K N{\"a}gga and Nilsson, {E D} and F Ricci and O Melander and O Hansson and E Bachus and A Fedorowski and M Magnusson",
year = "2020",
month = "5",
day = "15",
doi = "10.1038/s41598-020-64998-y",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}