High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events.

Research output: Contribution to journalArticle

Abstract

Rupture of atherosclerotic plaques is the major cause of acute coronary events (CEs). Plaque destabilization is the consequence of an imbalance between inflammatory-driven degradation of fibrous tissue and smooth muscle cell-dependent tissue repair. Proinflammatory factors have been documented extensively as biomarkers of cardiovascular risk but factors that contribute to stabilization of atherosclerotic plaques have received less attention. The present study aimed to investigate whether plasma levels of the smooth muscle cell growth factor epidermal growth factor (EGF), heparin-binding-EGF (HB-EGF), and platelet-derived growth factor correlate with plaque phenotype and incidence of CEs.

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Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
Original languageEnglish
Pages (from-to)222-228
JournalArteriosclerosis, Thrombosis and Vascular Biology
Volume35
Issue number1
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes

Related research output

Sara Rattik, 2015, Experimental Cardiovascular Research Unit, Lund University. 183 p.

Research output: ThesisDoctoral Thesis (compilation)

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