High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events.

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Bibtex

@article{291b823422864797b8e3a5d252fdb535,
title = "High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events.",
abstract = "Rupture of atherosclerotic plaques is the major cause of acute coronary events (CEs). Plaque destabilization is the consequence of an imbalance between inflammatory-driven degradation of fibrous tissue and smooth muscle cell-dependent tissue repair. Proinflammatory factors have been documented extensively as biomarkers of cardiovascular risk but factors that contribute to stabilization of atherosclerotic plaques have received less attention. The present study aimed to investigate whether plasma levels of the smooth muscle cell growth factor epidermal growth factor (EGF), heparin-binding-EGF (HB-EGF), and platelet-derived growth factor correlate with plaque phenotype and incidence of CEs.",
author = "Sara Rattik and Maria Wigren and Harry Bj{\"o}rkbacka and {Nordin Fredrikson}, Gunilla and Bo Hedblad and Agneta Siegbahn and Eva Bengtsson and Alexandru Schiopu and Andreas Edsfeldt and Pontus Dun{\'e}r and Helena Grufman and Isabel Goncalves and Jan Nilsson",
year = "2015",
doi = "10.1161/ATVBAHA.114.304369",
language = "English",
volume = "35",
pages = "222--228",
journal = "Arteriosclerosis, Thrombosis and Vascular Biology",
issn = "1524-4636",
publisher = "Lippincott Williams Wilkins Hagerstown, MD",
number = "1",

}