High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.

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Abstract

Islet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid. Amyloid fibrils form through smaller cell toxic intermediates and deposited amyloid disrupts normal islet architecture. Even though IAPP and amyloid formation are much discussed in type 2 diabetes, our aim was to study the significance of IAPP in type 1 diabetes.

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Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes
  • Pediatrics
Original languageEnglish
Article numbere93053
JournalPLoS ONE
Volume9
Issue number3
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes

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