High prevalence of ascending aortic dilation in adults with repaired coarctation of the aorta

Research output: Contribution to journalArticle

Abstract

Background: Ascending aortic dilation is a feared complication in adults with repaired coarctation of the aorta, as the condition is associated with life-threatening complications such as aortic dissection and rupture. However, the data are currently limited regarding factors associated with ascending aortic dilation in these patients. Methods and results: From the national register of congenital heart disease, 165 adult patients (≥ 18 years old) with repaired coarctation of the aorta, and echocardiographic data on aortic dimensions, were identified (61.2% male, mean age 35.8 ± 14.5 years). Aortic dilation (aortic diameters > 2 SD above reference mean) was found in 55 (33.3%) of the 165 included patients, and was associated with manifest aortic valve disease in univariable logistic regression analysis (OR 2.44, 95% CI [1.23, 4.83]). Conclusions: Aortic dilation is common post-repair of coarctation of the aorta, and is associated with manifest aortic valve disease and thus indirectly with the presence of a bicuspid aortic valve. However, no association was found between aortic dilation and age or blood pressure.

Details

Authors
  • Daniel Rinnström
  • Mikael Dellborg
  • Ulf Thilén
  • Peder Sörensson
  • Niels Erik Nielsen
  • Christina Christersson
  • Bengt Johansson
Organisations
External organisations
  • Umeå University
  • University of Gothenburg
  • Karolinska Institutet
  • Linköping University
  • Uppsala University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems

Keywords

  • aortic dilation, CoA, GUCH
Original languageEnglish
JournalCardiology in the Young
Publication statusE-pub ahead of print - 2021 Feb 18
Publication categoryResearch
Peer-reviewedYes