High risks of maternal and perinatal complications in singletons born after oocyte donation
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INTRODUCTION: Previous studies have shown an increased risk of obstetric complications in pregnancies after oocyte donation (OD). The present study includes all singletons born after OD during 10 years in Sweden.
MATERIAL AND METHODS: A retrospective cohort study that included data from all Swedish in vitro fertilization (IVF) clinics between 2003 and 2012 was performed. Data were cross-linked with the Swedish Medical Birth Registry. The study included 388 OD singletons, 26,696 IVF/ICSI singletons and 999,804 spontaneously conceived (SC) singletons. Adjusted odds ratio (AOR) was calculated with adjustment for relevant confounders.
RESULTS: Singleton OD pregnancies had a significantly increased risk of preeclampsia compared to IVF (AOR 3.05; 95% CI 2.23-4.16) and SC (AOR 2.84; 95% CI 2.10-3.84), increased risk of postpartum hemorrhage (>1000 ml) compared to IVF (AOR 2.66; 95% CI 2.04-3.49) and SC (AOR 2.87; 95% CI 2.20-3.71), higher risk of preterm birth (<37) compared to IVF (AOR 1.79; 95% CI 1.30-2.46) and SC (AOR 1.58; 95% CI 1.15-2.16) and low birth weight (<2500 g) compared to IVF (AOR 1.67; 95% CI 1.15-2.42) and SC (AOR 1.46; 95% CI 1.01-2.11). The rate of large for gestational age was significantly increased in singletons born after OD with frozen cycles compared to fresh cycles (odds ratio 5.29, 95% CI 1.30-21.54).
CONCLUSIONS: Singleton pregnancies conceived after OD are associated with increased maternal and perinatal risks compared to IVF/ICSI pregnancies using the woman's own oocytes and with SC. This article is protected by copyright. All rights reserved.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Acta Obstetricia et Gynecologica Scandinavica|
|Early online date||2016 Apr 6|
|Publication status||Published - 2016 Aug 1|